Pharmacological effects of Achyranthes bidentata. Effects on reproductive system;
The total saponins of Achyranthes bidentata have obvious concentration-dependent excitatory effect on rat uterine smooth muscle, the effect on young uterus is the weakest, and the effect on third trimester uterus is the strongest. Achyranthes bidentata saponin A has obvious exciting effect on the uterus of non-pregnant and pregnant rabbits. Oral administration of total saponins of Achyranthes bidentata in mice has obvious anti-implantation and anti-early pregnancy effects in a dose-dependent manner. The anti-early pregnancy effect of ABS can be partially antagonized by exogenous progesterone, human chorionic gonadotropin and tiapride. ABS can significantly inhibit decidual cell reaction in pseudopregnant mice and ovariectomized mice, but it has no estrogen-like effect and anti-estrogen-like effect.
2. Assimilate into protein:
After oral administration of ecdysterone or Achyranthes bidentata in mice, it was found that the quality of protein synthesized by amino acids in liver increased significantly, and its effect was similar to that of anabolic steroid 4- chlorotestosterone.
3. Effects on cardiovascular system:
The mixed saponin of Achyranthes bidentata seeds has obvious cardiotonic effect on isolated frog heart, guinea pig heart and rabbit heart. Achyranthes bidentata has antihypertensive effect, and when blood pressure drops, it is accompanied by respiratory excitement, but it has no rapid tolerance. The effective component of Achyranthes bidentata on animal blood pressure is mainly alkaloid.
4. Influence on blood system:
Achyranthes bidentata can reduce the whole blood viscosity, hematocrit and erythrocyte aggregation index in rats, and prolong the prothrombin time and plasma calcium recovery time in rats.
5. Anti-inflammatory and analgesic effects:
Achyranthes bidentata has anti-inflammatory and analgesic effects, and Achyranthes bidentata produced in Henan has the best analgesic effect. Different processed products of Achyranthes bidentata have a certain degree of analgesic effect, and the analgesic effect of Achyranthes bidentata processed with wine is strong and lasting. Compared with the anti-inflammatory effect of croton oil-induced ear swelling in mice, Achyranthes bidentata processed with wine has the strongest anti-inflammatory effect.
6. Effects on the immune system:
Achyranthes bidentata polysaccharide can improve the phagocytic function of mononuclear M in mice, and obviously improve the serum hemolysin level and the number of antibody-forming cells in mice. It has obvious enhancement effect on humoral immunity and nonspecific immunity of mice.
7. Anti-aging effect:
Achyranthes bidentata can improve the activity of SOD in whole blood and reduce the content of LPO in serum, which has the effect of delaying aging. Ecdysterone, the effective component of Achyranthes bidentata, and the decoction or alcohol extract of Achyranthes bidentata have certain anti-aging effects.
8. Effects on digestive system:
Achyranthes bidentata decoction has inhibitory effect on isolated intestine of mice, but has contractive effect on isolated intestine of guinea pigs. Intravenous injection of Achyranthes bidentata decoction can temporarily excite and then inhibit gastrointestinal motility in anesthetized dogs and normal or anesthetized rabbits. Ethanol extract of Achyranthes bidentata can excite isolated rabbit intestines (duodenum, jejunum and ileum), improve tension and enhance contractility.
9. Other roles:
Achyranthes bidentata polysaccharide sulfate has strong inhibitory activity on HBsAg and HBeAg of hepatitis B virus, and also has obvious inhibitory effect on herpes simplex virus type I. The water decoction or alcohol extract of Achyranthes bidentata is injected intravenously into anesthetized rabbits or dogs, which has a mild diuretic effect. The total saponins of Achyranthes bidentata have inhibitory effect on tumor cells.
10. Toxicity:
The LD50 of ecdysone contained in Achyranthes bidentata is 6.4g/kg in mice and 7.8g/kg in Achyranthes bidentata, both of which are >: 9g/kg.
The medicinal contraindication of Achyranthes bidentata is 1, so pregnant women should not take it.
2, amenorrhea time is not long, don't use it if you suspect elasticity, don't take medicine, and bloody collapse will be avoided.
3. Dreams have lost their essence and should be banned.
4, if diarrhea and spleen deficiency and leg and knee pain should not be used.
5, dirty and cold will slip, and those who are not solid will avoid it.
6, lack of gas, self-interested urination, are prohibited.
The medicinal prescription of Achyranthes bidentata is 1, which can cure dysuria, stem pain and abdominal pain: Achyranthes bidentata leaves a lot, not much, and drink with wine when cooked.
2, cure violence, there is a stone-like thing in the abdomen, the pain is like a thorn, crying day and night: two pounds of Achyranthes bidentata, with a barrel of wine, dipped in it, sealed, and tasted in hot charcoal fire, taking five to one liter, according to your ability.
3, can not be cured of clothing: Achyranthes bidentata eight two, sunflower one or two. Take nine liters of water, fry three liters and take three servings.
4, take the fetus: use one or two bull knees, a real musk, mash it evenly, dissolve the wax and rub it into long strips, insert it into the vulva, and you can have an abortion.
Treatment of laryngitis and moth: a handful of fresh Achyranthes bidentata and seven tablets of Artemisia argyi. Knife and human milk, take the juice and pour it into your nose, then spit it out from your mouth and nose. You can do without ai.
6. Treatment of carbuncle and furuncle ulceration: the root of Achyranthes bidentata is scraped and peeled slightly, inserted into the sore, leaving half an inch away, holding tender orange leaves and Euphorbia humifusa respectively, and tamping (applying) it, which varies with dryness.
7. Treating crane knee wind: decocting Achyranthes bidentata, Fructus Chaenomelis, Cortex Acanthopanacis, Rhizoma Drynariae, Flos Lonicerae, Herba Violae, Cortex Phellodendri, Rhizoma Dioscoreae Septemlobae and Flos Chamomillae in water.
8. Treat paralysis, tonify deficiency, strengthen bones and muscles, and eliminate chronic malaria: decoct Achyranthes bidentata in water and add koji rice wine, or chop up bagged wine and drink it after boiling.
9. Long-lasting tuberculosis: the longevity of Achyranthes bidentata. Cut, take six liters of water, boil two liters, and then take them separately. The first service is the service before taking food, and the second service is the temporary service.
10, first red and then white: Achyranthes bidentata. Mash, use a liter of wine, soak overnight, drink two cups at a time, three times a day.
1 1, for thirst and asthenia: five ounces of Achyranthes bidentata, fine judgment, five liters of Rehmannia glutinosa juice, soaking, soaking in the daytime, full of juice, big honey pills, and thirty hollow warm wine pills.
13, fatigue malaria accumulates over time. Take a handful of Achyranthes bidentata, cut it raw, add six liters of water, boil it into two liters, and take it three times (once in the morning, once before malaria, once when malaria is approaching).
14, furuncle has collapsed. Scrape the root of Achyranthes bidentata slightly, insert it into the sore, leaving half an inch outside, and mash it with a handful of tender orange leaves and a handful of Euphorbia humifusa.
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