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Drug name

Generic name: NaproxenTablets Previous name: trade name: English name: naproxen tablets Chinese pinyin: NaipushengPian The main component of this product is naproxen. The chemical name is (+)-α-methyl -6- methoxy -2- naphthylacetic acid. Its structural formula is: molecular formula: C 14H 14O3 molecular weight: 230.26.

composition

Character; Role; letter

This product is a white or white-like tablet.

Functional category

Pharmacology and toxicology

This product is a non-steroidal anti-inflammatory drug, which has analgesic, anti-inflammatory and antipyretic effects by inhibiting prostaglandin synthesis.

pharmacokinetics

After oral administration, the absorption is rapid and complete, and the blood drug concentration reaches the peak 2 ~ 4 hours after oral administration. When taken with food, magnesium and aluminum, the absorption rate will decrease, and when taken with sodium bicarbonate, the absorption rate will increase. The binding rate of plasma protein is higher than 99%. T 1/2 is generally 13 hours. It is metabolized in the liver and excreted by the kidneys. About 95% is excreted with urine in its original form and combined form.

indicate

Can be used for treating rheumatic and rheumatoid arthritis, gastroarthritis, ankylosing spondylitis, gout, arthritis and tenosynovitis. It can also be used to relieve pain caused by musculoskeletal sprain, contusion, injury and dysmenorrhea.

dosage

Adult oral dosage (1):① Anti-rheumatism, 0.25~0.5g in the morning and evening, or 0.25g in the morning and evening; ② Analgesia, 0.5g in the first time, 0.25g every 6-8 hours if necessary; ③ Acute attack of gouty arthritis, 0.75g for the first time and 0.25g for the second time, once every 8 hours until the acute attack stops; ④ Dysmenorrhea, 0.5g for the first time, and 0.25g if necessary later, once every 6-8 hours. (2) Common dosage for children: anti-rheumatism, 5mg/kg once per body weight, twice a day.

counteraction

(1) itchy skin, shortness of breath, dyspnea, asthma, tinnitus, edema of lower limbs, heartburn, indigestion, stomachache or discomfort, constipation, dizziness, drowsiness, headache, nausea and vomiting. (2) blurred vision or visual impairment, hearing loss, diarrhea, oral irritation or pain, palpitation and hyperhidrosis. (3) gastrointestinal bleeding and renal damage (allergic nephritis, nephropathy, renal nipple necrosis and renal failure, etc.). ), urticaria, allergic skin rash's disease, depression, myasthenia, bleeding or granulocytopenia, liver function damage and other rare.

taboo

Have a history of allergy to this product or similar drugs, and those who have asthma, rhinitis and nasal polyp syndrome caused by aspirin or other non-steroidal anti-inflammatory drugs are prohibited; Patients with active gastric ulcer and duodenal ulcer are prohibited.

Matters needing attention

(1) cross allergy. People who are allergic to aspirin or other NSAIDs are also allergic to this product. (2) Diagnostic interference: It may affect the measured values of urine 5- hydroxyindoleacetic acid (5-HIAA) and 17- ketosteroid. (3) Use with caution in the following situations: when there is coagulation mechanism or platelet dysfunction, asthma, cardiac insufficiency or hypertension, hepatic and renal insufficiency. (4) Long-term medication should include regular liver, renal function, hemogram and eye examination, and the dosage should be adjusted according to the patient's reaction to the drug. Generally, the lowest effective dosage should be used.

Medication for pregnant and lactating women

(1) The study on the effect of this product on fetus is not sufficient. Because other non-steroidal anti-inflammatory drugs can cause premature closure of fetal arterial duct, and because they can inhibit prostaglandin synthesis, which will lead to dystocia or prolonged labor, they are not suitable for pregnant women unless there are other reasons. (2) The concentration of this product secreted into milk is equivalent to l% of the blood drug concentration, so it is not suitable for lactating women.

Children's medication

Medication for elderly patients

Use with caution.

drug interaction

(l) When drinking alcohol or combining with other non-steroidal anti-inflammatory drugs, gastrointestinal adverse reactions increase and there is a risk of ulcer. (2) When combined with anticoagulants such as heparin and dicoumarin, the bleeding time will be prolonged, which may lead to bleeding tendency and gastrointestinal ulcer. (3) This product can reduce the sodium excretion and hypotensive effect of furosemide. (4) This product can inhibit lithium excretion with urine and increase the plasma concentration of lithium. (5) When it is combined with probenecid, the blood concentration of this product increases, and the T 1/2 is prolonged, which can increase the curative effect, but the toxic reaction also increases correspondingly, which is of no practical value and is not recommended for clinical use.

excessive

Excessive poisoning should be treated urgently, including vomiting or gastric lavage, oral active carbon and antacid, symptomatic support treatment and rational use of diuretics.

standard

(1)0. 1 g (2) 0.125g (3) 0.25g.

store

Shading, sealing and storage.

parcel

term of validity