Clearing away heat and detoxification; promoting blood circulation and eliminating carbuncles; eliminating wind and removing dampness and sores; snake and insect bites.
The main treatment of carbuncle; lung fever coughing; sore throat; dysentery; rheumatism paralysis; bruises; carbuncle cancer. Internal use: decoction, 15-30 grams; or powder.
Externally: appropriate amount, pounding juice or grinding juice to apply. Used for lung abscess, measles pneumonia, abscess around tonsils.
1, clinical use of the sore throat, often with the lantern grass, tendon grass, etc.; with the treatment of lung fever and cough, or carbuncle, can be used alone with one or two of this product, stewed water juice service, can also be used with the fish and other medicines with the use of fishweed. Treatment of hand and foot joints unfavorable, rheumatic tendon pain, often with the mulberry branches, Loxidou, Cangzhu and other drugs used together; with the treatment of dysmenorrhea and postpartum blood stasis obstruction abdominal pain and other conditions, can be used alone one or two of this product, plus brown sugar decoction.
2, wild buckwheat in the Shanghai area, known as the Chinese medicine store open gold locks, is named by the shape. This drug was not much clinical application, this product has a heat detoxification effect, with the treatment of lung abscess (carbuncle), the efficacy is very good, but it must be stewed juice decoction across the water; such as water decoction, the efficacy of the service is not obvious. After experience, the product stewed juice, taste very astringent, slightly bitter, with the treatment of acute bronchitis caused by cough phlegm, but also have efficacy, can make the phlegm secretion check to reduce, coughing gradually reduce.
3, the treatment of dysentery, enteritis.
4, treatment of lung abscess, chronic bronchitis.
5, treatment of lung cancer.
6, treatment of snake and insect bites.
7, (Quanzhan Xuanbian * tumor) treatment of nasopharyngeal carcinoma: fresh wild buckwheat, fresh Khan Fangji, fresh soil hyssop each 30 g. Decoction with water. Also take the heart of the lamp crushed orally, with the pitcher plant crushed external compresses. Buckwheat in the formula to clear heat and detoxification, blood circulation and wind-dampness, for the king drug.
8, ("Zhejiang Tianmu Mountain Pharmaceutical Plant Zhi") treatment of prolapse: fresh buckwheat, bitter ginseng 300 g. Water decoction, while hot smoke the affected area. Buckwheat in the formula to clear heat and detoxification, blood circulation, for the king drug.
9, ("National Compendium of Chinese Herbal Medicine") treatment of amenorrhea: wild buckwheat fresh leaves 90g (dry leaves 30g), pounded, mix 4 eggs, fried in tea oil, plus rice wine **** cooking, internal service. Buckwheat in the formula, blood, for the king drug. There are expectorant, antipyretic, anti-inflammatory, anti-tumor effects.
In vitro experiments, although there is no obvious antibacterial effect, but the coagulase of Staphylococcus aureus, hemolysin and Pseudomonas aeruginosa endotoxin has an antagonistic effect.
1, anticancer effect
Gold buckwheat root decoction 20g (raw) / (kg-d) and 13.3g (raw) / (kg-d) gavage, even
continued for 10d, Lewis lung cancer and cervical carcinoma in mice U14 have significant inhibition of the efficacy of the female mice better than the male mice. Using the mouse renal capsule transplantation method (SRCA), to compare the volume of lung cancer tissue before and after transplantation in order to predict and evaluate the anticancer effects of gold buckwheat extract gold E and CD1. 1-5d after SRCA, mice were orally administered five consecutive gold E or CD1, the dose of 100mg/kg each time, the test results showed that the effective ratio of gold E and CD1 is 4/0 and 2/l0, lung squamous carcinoma on the gold E treatment is more sensitive than other tissue types of lung cancer. Fagopyrum Cymosum Rootin (FCR) is a comprehensive class of tannin mixtures proposed from buckwheat root, the concentration of 125 μg per 1 ml, the inhibition rate of lung adenocarcinoma GLC), cervical squamous carcinoma HeLa), nasopharyngeal squamous carcinoma (KB) cell growth of 84.5%, 78.9 %, 100%, respectively, so that the cancer cells of the membrane, RNA, DNA metabolism, and nuclear division were damaged. FCR was also found to significantly inhibit GLC, Hela, KB and gastric adenocarcinoma cells (SGC) human cancer cell clone formation, the inhibition rate is directly proportional to the concentration, in the low concentration of 12.5 μg / ml inhibition rate of 89.7%, GLC, HeLa53.8%, SGC65.4%, K to kill the cells, colony culture inhibition and DNA precursor material doping method. To study the anticancer effect of gold buckwheat root on a variety of human cancer cells cultured in vitro. As a result, the killing rate of this drug in lg/L on a variety of human cancer cells are more than a logarithmic killing, the concentration was reduced to 0.125g/L killing rate is still close to a logarithmic killing of 74.3%-92.1%. Buckwheat root extract has a significant anticancer effect, its concentration of 0.1g / L, 0.05g / L on a variety of cancer cell colonization inhibition rate of 100%. The inhibition rate reached 75.1%-89.2% at the concentration of 0.0125g/L. The concentration of 0.0125g/L was 0.0125g/L, 0.05g/L, and 0.05g/L, respectively. It was further observed by 3H-TdR labeling method that the effective chemical extract of buckwheat root could significantly inhibit nucleic acid metabolism in cancer cells, and its inhibitory effect was similar to that of the positive control fluorouracil at the same concentration.
2, antibacterial effect
Buckwheat on Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Pseudomonas aeruginosa have inhibitory effect, the effect of drunkenness is greater than that of water. It has also been reported that buckwheat and its isolates have no in vitro antibacterial effect, in different periods before the infection of buckwheat intraperitoneal injection of buckwheat extract 83mg/kg, abdominal infection of Staphylococcus aureus mice have a significant protective effect, but at the same time in the infection or post-infection with the drug has no protective effect.
3, other effects
Gold buckwheat extract 83mg/kg intraperitoneal injection, can enhance the phagocytosis of macrophages in the abdominal cavity of mice, but the total number of macrophages did not see an increase. Triple vaccine fever rabbits orally administered buckwheat extract has antipyretic effect, to mice orally administered buckwheat extract has a slight antitussive effect.
Buckwheat protein is rich in lysine content, iron, manganese, zinc and other trace elements than the average grain, and rich in dietary fiber, is generally 10 times the refined rice, so buckwheat has a good nutritional health effects;
Wheat is rich in vitamin E and soluble dietary fiber, and also contains niacin and rutin (rutin), rutin has a lower body blood lipids and cholesterol, soften blood vessels, vision protection and prevention of cerebrovascular hemorrhage;
Buckwheat contains niacin can promote the body's metabolism, enhance the ability to detoxify, but also has the expansion of small blood vessels and reduce blood cholesterol;
Buckwheat is rich in magnesium, which can promote the human body's fibrinolytic, vasodilatation, inhibit the formation of blood clots, with an anti-embolism
4, toxicity
Golden buckwheat extract gold E group of mice 100mg/kg, 5d consecutive oral administration, the animal's body weight and spleen weight than the control group was significantly reduced, the dose, such as increasing to 500mg/kg, the spleen weight reduction is more pronounced. Character identification
The rhizome is irregular lumpy, often with verrucose branches, length, size, 1-4cm in diameter, the surface is brown to gray-brown, with dense links and irregular longitudinal wrinkles, as well as a large number of fibrous roots or fibrous root scars; the tip of the stem stumps. The texture is hard, not easy to break, the cut surface is light yellowish white to yellowish brown, with radial texture, and there is pith in the center. It is slightly astringent in odor and taste.
The one with big and hard texture is better.
Microscopic identification
Transverse section of the rhizome: the cork layer is 4-5 rows of cork cells, all containing brown material. The cortex is narrower, and the thin-walled cells contain calcium oxalate cluster crystals. The phloem has a few fibers scattered. The xylem is in two layers, inside and outside, resembling an annual cycle; the outer layer is wider, with thin-walled wood-thin-walled cells, large and sparse ducts, and narrowly oblong wood-ray cells; the inner layer is narrower, with thicker wood-thin-walled cells, and small ducts, arranged in a single radial row. Pith cells rounded, wall thicker.
Powder characteristics: light red. The starch grains are rounded, 4-30μm in diameter, and the umbilical dots are dotted. ②Calcium oxalate cluster crystals 20-50μm in diameter. ③Carpophore ducts are common. ④The bast fibers are less common.
The powder is light brown. Starch grain is very much, single grain spherical, ellipsoid or ovoid, 5～48μm in diameter, umbilical dot dot, stellate, slit or bird-like, located in the center or at one end, large grains can be seen laminar pattern; compound grains consist of 2～4 grains; semi-complex grains can be seen. Wood fibers in bundles, 10-38 μm in diameter, with single oblique or cross-shaped pores. Calcium oxalate clusters 10-62 μm in diameter; wood thin-walled cells square and ellipsoid, 28-37 μm in diameter, about 100 μm in length, wall thickness of about 5 μm, with sparse perforations in the lumen. The diameter of ciliated pores and reticulated ducts is 21～83μm.
Physical and chemical identification
(1) Take 1g of crude powder, add 50ml of ethanol and reflux extraction for 2h, take l-2 drops of ethanol extract, put it into a test tube, add floral pigment reagent (60ml of n-butanol mixed with 40% of hydrochloric acid 40ml, and then add FeSO4.7H2O 77mg dissolved 2ml, and heat it for 5ml on a boiling water bath, and then add 2ml of FeSO4.7H2O 77mg. Boiling water bath heating for 5min, the solution was cherry red. (Check the reduction of anthocyanin dimer)
(2) electrophoresis: take the alcohol extracted liquid point in the new China 1 filter paper strip (5cm × 30cm), with boric acid - borax buffer (pH = 8.8), voltage 200V, current 0.3mA, electrophoresis 7h, air drying, observation of fluorescence, spraying p-toluenesulfonic acid reagent (20% ethanol), 100 ℃ baked for 5min, about in the origin of the red-brown spots. Reddish brown spot at 17cm. Take 1g of powder, add chloroform 10ml, impregnated for 30 minutes, shaking, filtered, filtrate evaporation, residue with chloroform 1ml to dissolve, as a test solution. Another take buckwheat control herb 1g, the same method into the control herb solution. According to thin-layer chromatography, absorb the above two solutions of 2 ~ 3μl, were spotted on the same silica gel G thin-layer plate, chloroform - methanol (19:1) as an unfolding agent, unfolding, remove, drying, sprayed with 10% sulfuric acid ethanol solution, heated until the spots show clear color. In the chromatogram of the test article, in the corresponding position with the chromatogram of the control herb, the spots of the same color.