The specific route is as follows:

1. Take Metro Line 2 from Guangyi Station to Guangzhou South Station, and take 4 stops to Shibi Station.

2. At Shibi Station, transfer to higher education mega center south on Metro Line 7, and then take five stops to higher education mega center south.

3. Transfer to Metro Line 4 in the south of the University Town to the direction of Huangcun, and then take 3 stops to the North Station of the University Town.

4. Transfer to Tianhe Bus Terminal of Metro Line 3 at University Town North Station, and take 1 station to Guanzhou Station.

5. Exit at the entrance and exit of Guanzhou Station and walk for about 15 minutes to reach Guangdong Science Center.

The whole journey takes about 40 minutes. It should be noted that the operating hours and fares of the subway may change according to the specific timetable and policies, so it is best to check the latest subway service information and prepare the appropriate fares before the actual trip.