Huang (attending physician of dermatology, Chang Gung Hospital) 45-year-old Mr. Wei, a white spot clinic related to tumor diseases, suddenly found that there were white spots around the moles all over his body, also known as halo moles. After careful examination, Mr. Wei had a strange-looking mole, which was confirmed by biopsy as malignant melanoma. In fact, the white spot reaction in the body is due to the immune response of immune cells to melanocytes. (Editor's recommendation: The more moles, the easier it is to get skin cancer? There are five kinds of moles that are the most dangerous in appearance. Halo nevus Halo nevus is a special kind of nevus, which is mainly manifested by halo-like white spots around the nevus. With the appearance of halo leukoplakia, the central nevus may flatten or disappear with time, and the shape of leukoplakia may last for a long time or continue to expand. It is often observed that halo nevus and leukoplakia appear at the same time in clinic. At present, it is speculated that melanocytes and melanocytes in normal epidermis may be destroyed because of the immune cross-reaction of immune cells to melanocytes. But it must be noted that the mole in the center of halo nevus is normal. Because the central part of halo nevus may be malignant melanoma, and the body tries to produce an immune response to attack the abnormal melanocytes of melanoma, but because of the lack of specificity, it attacks other skin melanocytes and nevus by the way, resulting in white spots and halo nevus reactions. Mushroom granuloma This is a kind of malignant skin lymphoma, some of which will appear white spots in various parts of the body, accompanied by emaciation, lymphadenopathy and other symptoms. The diagnosis must be made by skin biopsy. Mushroom granuloma is a very difficult disease to diagnose, and sometimes it takes many slices to make a definite diagnosis. The prognosis of early diagnosis is almost normal. However, if the treatment is delayed, lymphoma will spread to the whole body, affecting the survival rate of patients. The nutritional deficiency of white spots related to nutritional deficiency may also cause the formation of white spots, but this situation is not easy to see in today's rich material living environment. Leukoplakia caused by nutritional deficiency mainly occurs in patients with protein's disease. In addition to the red peeling of the skin, there will be white spots of different sizes. Most of them appear on the face, and these white spots will disappear with the increase of protein intake. If white spots appear in a large area and a wide range, it may also be related to trace elements copper and selenium. Huang (attending physician of dermatology, Chang Gung Hospital) 45-year-old Mr. Wei, a white spot clinic related to tumor diseases, suddenly found that there were white spots around the moles all over his body, also known as halo moles. After careful examination, Mr. Wei had a strange-looking mole, which was confirmed by biopsy as malignant melanoma. In fact, the white spot reaction in the body is due to the immune response of immune cells to melanocytes. (Editor's recommendation: The more moles, the easier it is to get skin cancer? There are five kinds of moles that are the most dangerous in appearance. Halo nevus Halo nevus is a special kind of nevus, which is mainly manifested by halo-like white spots around the nevus. With the appearance of halo leukoplakia, the central nevus may flatten or disappear with time, and the shape of leukoplakia may last for a long time or continue to expand. It is often observed that halo nevus and leukoplakia appear at the same time in clinic. At present, it is speculated that melanocytes and melanocytes in normal epidermis may be destroyed because of the immune cross-reaction of immune cells to melanocytes. But it must be noted that the mole in the center of halo nevus is normal. Because the central part of halo nevus may be malignant melanoma, and the body tries to produce an immune response to attack the abnormal melanocytes of melanoma, but because of the lack of specificity, it attacks other skin melanocytes and nevus by the way, resulting in white spots and halo nevus reactions. Mushroom granuloma This is a kind of malignant skin lymphoma, some of which will appear white spots in various parts of the body, accompanied by emaciation, lymphadenopathy and other symptoms. The diagnosis must be made by skin biopsy. Mushroom granuloma is a very difficult disease to diagnose, and sometimes it takes many slices to make a definite diagnosis. The prognosis of early diagnosis is almost normal. However, if the treatment is delayed, lymphoma will spread to the whole body, affecting the survival rate of patients. The nutritional deficiency of white spots related to nutritional deficiency may also cause the formation of white spots, but this situation is not easy to see in today's rich material living environment. Leukoplakia caused by nutritional deficiency mainly occurs in patients with protein's disease. In addition to the red peeling of the skin, there will be white spots of different sizes. Most of them appear on the face, and these white spots will disappear with the increase of protein intake. If white spots appear in a large area and a wide range, it may also be related to trace elements copper and selenium. Aunt Wang, a 60-year-old patient with chronic arsenic poisoning, recently found two protruding tumors on her right shoulder and back, forming an open wound. Dressing for a long time, she didn't recover. After the biopsy, she was diagnosed as squamous cell carcinoma. Examining Aunt Wang's skin carefully, I found that her skin showed many mottled black and white spots of different sizes. The whole skin was colorful and there were tiny pits on her palm. In addition to the two protruding tumors, there are many precancerous lesions in other parts of Aunt Wang's skin. After careful inquiry, I found that Aunt Wang grew up in a nearby place where she used to drink well water. These skin manifestations are caused by chronic arsenic poisoning, and the source of arsenic is probably related to the well water where Aunt lives. (Editor's recommendation: Yan Zonghai: Drinking bad water leads to liver and kidney problems! Rule 3: Drink healthy water, don't drink poison) Chronic arsenic poisoning was very common in early Taiwan Province Province, because non-public tap water sources were used, such as well water or farmers. Arsenic is widely used as an insecticide, and farmers often use it to prevent pests, but drugs may seep into well water or drinking water sources with soil. Chronic arsenic poisoning skin will appear black and white spots, palm will appear many pits, accompanied by many in-situ squamous cell carcinoma, which will easily evolve into squamous cell carcinoma over time and may metastasize. In addition to skin cancer, chronic arsenic poisoning can also lead to chronic respiratory tract obstruction, liver cirrhosis, myocardial infarction, mental disorders, pregnancy malformation and so on. , or limb terminal necrosis caused by severe obstruction of peripheral blood vessels, is called "Blackfoot disease". This article is taken from Black Spots and White Spots/Huang (Dermatologist, Chang Gung Hospital)/Dakuai Culture.