1 Anemia is the first symptom of childhood leukemia. Bone marrow is the most important hematopoietic organ of human body. Bone marrow is invaded by a large number of leukemia cells, and the hematopoietic system fails, which leads to the decline or even disappearance of the viability of red blood cells and hemoglobin, causing anemia in children to varying degrees, mainly manifested as pallor, collapse, sweating and facial edema. People will feel short of breath and their hearts will beat faster, no matter when they are exercising or resting. As time goes on, anemia becomes more and more serious.

2 children with fever leukemia often have fever, which can be low fever (37.5 -38 degrees), irregular fever, or high fever. One of the causes of fever is tumor fever, that is, leukemia cells release pyrogen themselves, causing body temperature to rise, and another reason is secondary infection, causing body fever.

3 Hemorrhage In the whole course of leukemia children, almost all children will have bleeding to varying degrees. The most common bleeding sites are skin and mucous membranes, which are often manifested as skin bleeding spots or ecchymosis, nosebleeds, gingival bleeding, blood bubbles in the mouth and tongue, etc. Severe children may have visceral bleeding, such as hematemesis, expectoration, hematuria and melena. Some children may suffer from fundus hemorrhage, resulting in decreased vision and blindness, and even death. The occurrence of bleeding is related to the invasion of leukemia cells into normal bone marrow, which leads to abnormal platelets.

4 Most children with hepatosplenomegaly leukemia will have superficial lymphadenopathy, which is more common in submandibular, neck, clavicle, armpit and groin, and often has no obvious pain. Physical examination can find hepatosplenomegaly and obvious tenderness under the sternum, which is the performance of a large number of leukemia cells invading bone marrow.