The stems and leaves of cocklebur contain substances that are toxic to nerves and muscles. After poisoning, symptoms include general weakness, dizziness, nausea, vomiting, abdominal pain, constipation, difficulty breathing, irritability, cold hands and feet, and slow pulse. Severe cases may cause jaundice, epistaxis, or even coma, body temperature drops, blood pressure fluctuates, or widespread bleeding, and finally death due to respiratory and circulatory failure.

Precautions

Contraindications: Do not take it if you have headache or numbness due to blood deficiency.

Toxic and side effects: reduced activity, slow response to external stimuli, irregular breathing, extremely difficult breathing before death, accompanied by paroxysmal convulsions. Histopathological examination showed that the liver damage was the most serious, namely seed kernel. The main cause of infusion poisoning is liver necrosis, followed by convulsions caused by brain tissue edema, which may be the direct cause of death.

Clinical overdose of this product (more than 30g) or accidental ingestion of Xanthium fructus L. More than 10 pills can cause poisoning, which usually occurs within 1 to 3 days. The poisoning reactions vary in severity. Generally, they include dizziness, headache, fatigue, lethargy, loss of appetite, nausea, vomiting, abdominal pain, diarrhea, or fever, facial complexion, etc. Flushing, conjunctival congestion, urticaria, etc.; in severe cases, irritability or drowsiness, coma, convulsions, arrhythmia, elevated blood pressure, jaundice, hepatomegaly, liver function damage, bleeding, casts and red blood cells in the urine, and urine Closure, etc. Hepatic coma, liver and kidney failure or respiratory failure may occur due to massive necrosis of liver cells. There have been clinical reports of death from overdose of Xanthium sibiricum (600 grams for children within two days).