Catalog 1 Pinyin 2 National Essential Drugs 3 Yin Qiao Antidote Tablet Poisoning 3.1 Adverse Reactions 3.2 Treatment 4 Pharmacopoeia Standard for Yin Qiao Antidote Tablet 4.1 Name 4.2 Prescription 4.3 Preparation 4.4 Characteristics 4.5 Identification 4.6 Examination 4.7 Determination of Contents 4.7.1 JINYUANHUA 4.7.1.1 Chromatographic Conditions and System Suitability Tests 4.7.1.2 Preparation of the Control Solution 4.7. 5.1 Types of drugs 5.2 Names of drugs 5.3 Pinyin of drugs 5.4 Ingredients 5.5 Properties 5.6 Functions and Indications 5.7 Dosage and Administration 5.8 Precautions 5.9 Interactions between Yinchiao and other drugs 5.10 Remarks 6 References 1 Yinchiao and Toxin Dispelling Tablet in Ancient Texts * Other versions of Yinchiao and Toxin Dispelling Tablet 1 Pinyin

Yinqiao qiào jiào jiào ( 拼音

) yín qiào jiě dú piàn

2 National Essential Drugs

National Essential Drugs Retail Price Information Related to Yin Qiao Antidote Tablets

No. Essential Drugs

Catalog No. Name of Drug Formulation Specification Units Retail Price

Guiding Price Category Remarks 36 4 Yin Qiao Antidote Tablets Tablets 24 tablets (sugar-coated) box (bottle) 3.6 Proprietary Chinese Medicines (PCMs) *(refers to the dosage of 4 tablets once, 2-3 times a day) 37 4 Yin Qiao Antidote Tablets Tablets 8 tablets (sugar-coated) Box (bottle) 1.2 Proprietary Chinese Medicine Part 38 4 Yin Qiao Antidote Tablets Tablets 12 tablets (sugar-coated) Box (bottle) 1.8 Proprietary Chinese Medicine Part 39 4 Yin Qiao Antidote Tablets Tablets 18 tablets (sugar-coated) Box (bottle) 2.7 Proprietary Chinese Medicine Part 40 4 Yin Qiao Antidote Tablets Tablets 20 tablets (sugar-coated) Box (bottle) 3 Proprietary Chinese Medicines Section 41 4 Yin Qiao Antidote Tablets Tablets 30 Tablets (sugar-coated) Box (bottle) 4.5 Proprietary Chinese Medicines Section 42 4 Yin Qiao Antidote Tablets Tablets 36 Tablets (sugar-coated) Box (bottle) 5.3 Proprietary Chinese Medicines Section 43 4 Yin Qiao Antidote Tablets Tablets 40 Tablets (sugar-coated) Box (bottle) 5.9 Proprietary Chinese Medicines Section 44 4 Yin Qiao Antidote Tablets Tablets 48 Tablets (sugar-coated) Box (bottle) 7 Proprietary Chinese Medicines Section 45 4 Yin Qiao Antidote Tablets Tablets 50 Tablets (sugar-coated) Box (bottle) 50 Tablets (sugar-coated) Box (bottle) 7.3 Proprietary Chinese Medicines Section 46 4 Yin Qiao Antidote Tablets Tablets 54 Tablets (sugar-coated) Box (bottle) 7.9 Proprietary Chinese Medicines Section 47 4 Yin Qiao Antidote Tablets Tablets 60 Tablets (sugar-coated) Box (bottle) 8.7 Proprietary Chinese Medicines Section 48 4 Yin Qiao Antidote Tablets Tablets 80 Tablets (sugar-coated) Box (bottle) 11.5 Proprietary Chinese Medicines Section 49 4 Yin Qiao Antidote Tablets Tablets 96 Tablets (sugar-coated) Box (bottle) 13.7 Proprietary Chinese Medicines Section 50 4 Forbesia Antidote Tablets Tablet 100 Tablets (sugar-coated) Box (bottle) 14.2 Proprietary Chinese Medicines Section 51 4 Forbesia Antidote Tablets Tablet 12 Tablets (film-coated) Box (bottle) 2 Proprietary Chinese Medicines Section 52 4 Forbesia Antidote Tablets Tablet 24 Tablets (film-coated) Box (bottle) 4 Proprietary Chinese Medicines Section 53 4 Forbesia Antidote Tablet Tablet 40 Tablets (film-coated) Box (bottle) 6.5 Proprietary Chinese Medicines Section 54 4 Forbesia Antidote Tablets Tablet 60 Tablets (sugar-coated) Box (bottle) Yin Qiao Antidote Tablet 60 Tablets (film-coated) Box (bottle) 9.6 Part of Proprietary Chinese Medicines

Note:

1. The dosage forms marked with "*" in the Remarks column of the table are representative products.

2. The dosage form specifications marked with "△" in the Remarks column of the table, and other specifications of the same dosage form are temporary prices.

3. For dosage form specifications with dosage indicated in the Remarks column, the prices of other specifications in the dosage form are calculated based on the same dosage and in accordance with the "Pharmaceutical Differential Pricing Rules".

4. The "honey pill" labeled in the dosage form column of the table includes small honey pill and large honey pill.

3 Yin Qiao Antidote Tablets for Poisoning

Main ingredients: honeysuckle, burdock, forsythia and platycodon, light lotus leaves, thorns, licorice, tempeh, etc. It has the effect of pungent, cool and detoxification, clearing away heat, and so on. There are pungent and cool to resolve the table, clearing heat and detoxification effect. It is used in the treatment of wind-heat cold, fever and headache, cough, dry mouth and sore throat. [1]?

3.1 Adverse reaction manifestations

Anaphylaxis manifests as dizziness, nausea, palpitations, cyanosis of the lips and mouth, numbness of the limbs, drop in blood pressure, shock, generalized mass-like papules, and severe cases can be fatal. It can also cause limited angioneurotic edema, eyelid and facial swelling. [1]?

3.2 Treatment

The main points in the treatment of poisoning from silvercordon bleu tablets are [1]? :

Symptomatic treatment.

4 Yinqiao Jiedu Pian Pharmacopoeia Standard 4.1 Name

Yinqiao Jiedu Pian

Yinqiao Jiedu Pian

4.2 Prescription

200g of honeysuckle, 200g of forsythia, 120g of peppermint, 80g of thorns, 100g of tempeh, 120g of burdock, 120g of platanum, 80g of tangerine leaves, 100g of licorice < /p> 4.3 Method

The above nine flavors, honeysuckle, eustoma were crushed into fine powder, sieve; mint, thuja extract volatile oil, the distillation of the aqueous solution collected in another vessel; dregs of the drug with forsythia, burdock, licorice and water decoction for two times, each time for 2 hours, filtration, combined filtrate; edamame boiled in water, at 80 ℃ temperature immersion for two times, each time for 2 hours, combined with the leachate, filtration. Combine the above liquids, concentrated into a thick paste, add honeysuckle, orange blossom fine powder and starch or talcum powder, mix well, made of granules, dry, cool, add magnesium stearate, sprayed with peppermint, thuja volatile oil [2], mix well, pressed into 1000 tablets, or wrapped in film coat, that is, obtained.

4.4 Character

This product is light brown to brown tablets or film-coated tablets, remove the coating light brown to brown; gas aromatic, bitter, pungent flavor.

4.5 Identification

(1) take the product, placed under the microscope: pollen grains spherical, diameter of about 76 μm, the outer wall has a spiny sculpture, with three germination holes; calcium oxalate clusters crystallized into pieces, diameter of 5 ~ 17 μm, present in the thin-walled cells (honeysuckle). Associated lactiferous tubules 14 to 25 μm in diameter, containing yellowish granular material (Platycodon grandiflorum).

(2) take 10 tablets of this product, film-coated tablets to remove the coating, research fine, add 20ml of ethanol, heating reflux for 1 hour, cooling, filtration, filtrate evaporation, residue add 2ml of ethanol to make dissolved, filtration, filtrate as a test solution. Another take honeysuckle control herb 0.3g, add ethanol 20ml, heating reflux 20 minutes, cooling, filtration, filtrate evaporation, residue add ethanol 2ml to dissolve, filtration, filtrate as the control herb solution. Then take chlorogenic acid control product, add methanol to make a solution containing 1mg per 1ml, as the control solution. According to the thin layer chromatography (2010 version of the Pharmacopoeia, Appendix VI B) test, absorb the above three solutions of 1 ~ 2μl, respectively, point in the same silica gel G thin layer plate, with butyl acetate - formic acid - water (7: 2.5: 2.5) of the upper solution as the unfolding agent, unfolding, take out, drying, and placed in the ultraviolet lamp (365nm) The chromatograms of the test articles were examined under a UV lamp (365 nm). In the chromatogram of the test article, in the corresponding position with the chromatogram of the control herb and the chromatogram of the control article, the fluorescent spots of the same color.

(3) Take 1g of forsythia control herb, add 40ml of water, impregnated in a water bath for 1 hour, filtered, filtrate evaporated, residue with 20ml of ethanol, heated to reflux for 20 minutes, cooled, filtered, filtrate evaporated, residue with 2ml of ethanol to make soluble, filtered, filtrate as a solution of control herb. According to the thin-layer chromatography (2010 version of the Pharmacopoeia a Appendix VI B) test, absorb the above control herb solution 2μl and [identification] (2) under the test solution 10μl were spotted on the same silica gel G thin layer plate, trichloromethane - methanol (20: 1) as an unfolding agent, unfolding, take out, drying, spraying acetic anhydride - sulfuric acid (20: 1) mixture, and then sprayed with acetic acid. Sulfuric acid (20:1) mixed solution, heated at 105 ℃ until the spot color is clear, cooled, placed in the ultraviolet light (365nm) under the examination. In the chromatogram of the test product, in the corresponding position with the chromatogram of the control herb, the fluorescent spots of the same color.

(4) take 10 tablets of this product, film-coated tablets to remove the coating, research fine, add petroleum ether (60 ~ 90 ℃) 20 ml, tightly plugged, ultrasonic treatment for 20 minutes, filtration, filtrate evaporated to about 1 ml, as the test solution. Take 0.4g of control herb, add petroleum ether (60～90℃) 20ml, the same method into the control herb solution. Then take menthol control, add ethanol to make a solution containing 2mg per 1ml, as the control solution. According to the thin-layer chromatography (2010 Pharmacopoeia, Appendix VI B), absorb 2-5μl of the test solution, 5μl of the control solution, 1μl of the control solution, and put them on the same silica gel G thin-layer plate, unfold them with n-hexane - ethyl acetate (17:3) as the unfolding agent, remove them, let them dry, and then spray them with 5% vanillin sulfuric acid solution, and heat them up at 105°C until the color of the spots becomes clear. Heating until the spots showed clear color. In the chromatogram of the test article, in the corresponding position with the chromatogram of the control herb and the chromatogram of the control article, the spot of the same color.

(5) take burdock control herb 1.2g, licorice control herb 1g, respectively, add 20ml of ethanol, heating reflux for 1 hour, filtration, filtrate evaporation, residue, respectively, add 2ml of ethanol to make soluble, filtration, filtrate as the control herb solution. According to the thin-layer chromatography (2010 version of the Pharmacopoeia a Appendix VI B) test, absorb [identification] (2) under the test solution 2 ~ 5 μl and the above two kinds of control herbal solution each 2 μl, respectively, point in the same silica gel G thin-layer plate, trichloromethane - methanol - water (40: 10: 1) as an unfolding agent, unfolding, remove The plate was dried, sprayed with 10% ethanol sulfate solution, and heated at 105℃ until the color of the spots became clear. In the chromatogram of the test material, respectively, in the corresponding position with the chromatogram of the control herb, the same color spots.

4.6 Inspection

It should comply with the relevant provisions under tablets (2010 version of Pharmacopoeia I Appendix I D).

4.7 Determination of content 4.7.1 Honeysuckle

Determined by high performance liquid chromatography (2010 version of Pharmacopoeia, Appendix I, D).

4.7.1.1 Chromatographic conditions and system suitability test

Octadecylsilane-bonded silica gel was used as filler; acetonitrile-0.3% phosphoric acid solution (10:90) was used as the mobile phase; the detection wavelength was 327 nm; and the theoretical plate number was not less than 3,000 according to the peak of chlorogenic acid.

4.7.1.2 Preparation of the control solution

Take the appropriate amount of chlorogenic acid control, precision weighing, placed in a brown measuring flask, add 50% methanol to make a solution containing 30 μg per 1 ml, that is obtained.

4.7.1.3 Preparation of test solution

Take 10 tablets of this product, film-coated tablets to remove the coating, precision weighing, research fine, take about 0.3g, precision weighing, placed in a stoppered conical flask, precision add 50% methanol 50ml, tightly stoppered, weighing, ultrasonic treatment (power 250W, frequency 35kHz) for 20 minutes, cool, and then weighing, make up for the weight of the loss of methanol. Weigh again, make up the lost weight with methanol, shake well, filter, take the filtrate, that is obtained.

4.7.1.4 Determination

Precisely draw 10μl of control solution and test solution respectively, inject into the liquid chromatograph, and then determine, it is obtained.

Each tablet of this product contains not less than 2.7mg of honeysuckle in terms of chlorogenic acid (C16H18O9).

4.7.2 Forsythia

Determined by high performance liquid chromatography ((2010 version of the Pharmacopoeia, a Appendix VI D).

4.7.2.1 Chromatographic conditions and system suitability test

Octadecylsilane-bonded silica gel as filler; acetonitrile-water (19:81) as mobile phase; the detection wavelength is 230 nm; the theoretical plate number of the forsythia glycoside peaks should not be less than 3,000.

4.7.2.2 Preparation of the control product

Take the appropriate amount of the control product, weigh it precisely and determine the amount.

Take the appropriate amount of forsythia glycoside control, weigh it precisely, add methanol to make a solution containing 25ug per 1ml, i.e., it is obtained.

4.7.2.3 Preparation of test solution

Take 10 tablets of this product, film-coated tablets to remove the coating, precision weighing, research fine, take about 2g, precision weighing, placed in a stoppered conical flask, precision add 50ml of methanol, tightly stoppered, weighing, ultrasonication (power 250W, frequency 35kHz) for 30 minutes, cooled, and then weighed, and then make up for the loss of weight with methanol, shaking. Then filtered, take 25ml of filtrate, evaporate to dry, add 0.5g of neutral alumina, add it on neutral alumina column (100-200 mesh, 1g, inner diameter is 1-1.5cm), elute with 70% ethanol 80ml, collect the eluent, concentrate it to dryness, add 50% methanol to make the residue soluble, transfer it to 10ml measuring flask, dilute it to the scale, shake it well, filter it, that is to say. Take the filtrate, that is obtained.

4.7.2.4 Determination

Precisely suck up the control solution and test solution 10μl each, injected into the liquid chromatograph, determination, that is, obtained.

Each tablet of this product contains not less than 0.10mg of forsythia in terms of forsythia glycoside (C27H34O11).

4.8 Functions and Indications

Expelling wind and relieving epidemics, clearing heat and removing toxins. It is used for wind-heat cold with fever, headache, cough, dry mouth and sore throat.

4.9 Dosage and Administration

Oral. 4 tablets at a time, 2-3 times a day.

4.10 Specifications

(1) Vegetarian tablets Each tablet weighs 0.5g[2]

(2) Film-coated tablets? Each tablet weighs 0.52g

4.11 Storage

Sealed.

4.12 Version

Chinese People's **** and National Pharmacopoeia 2010 Edition

5 Instructions for Yinqiao Jiedu Pian 5.1 Type of medicine

Traditional Chinese medicine

5.2 Name of medicine

Yinqiao Jiedu Pian

5.3 Hanyu Pinyin of medicine

Yinqiao Jiedu Pian

5.4 Ingredients

JINYINHUA, LIANQIAO, MINT, Thuja, Tempeh, Burdock seed (fried), Platycodonopsis, Mentha piperita, Glycyrrhiza glabra

5.5 Characteristics

Yinqiao Jiedu Pian is light brown to brown tablets or film-coated tablets, and after removing the coating, it appears light brown to brown; it has an aromatic odor, bitter taste, and pungent flavor.

5.6 Functions and Indications of Yin Qiao Xie Toxin Relief Tablets

To relieve wind and relieve the symptoms of cold and flu, clearing away heat and removing toxins. It is used for wind-heat cold, with fever and headache, cough and dry mouth, sore throat.

5.7 Usage and dosage

Oral. 4 tablets at a time, 2-3 times a day.

5.8 Precautions

1. Avoid smoking, alcohol and spicy, cold, greasy food.

2. It is not advisable to take tonic Chinese medicine at the same time during the medication.

3. Not suitable for people with wind-cold flu.

4. People with high blood pressure, heart disease, liver disease, diabetes, kidney disease and other serious chronic diseases should take under the guidance of a physician.

5. Children, pregnant women, lactating women, the elderly and weak, and those with spleen deficiency and loose stools should be taken under the guidance of a physician.

6. Patients with fever and body temperature over 38.5℃ should go to the hospital.

7. If the symptoms are not relieved after 3 days of taking the medicine, you should go to the hospital.

8. Allergic to Yin Qiao Xie Tu Wei Tablet is prohibited, allergic people should be cautious.

9. Yin Qiao Antidote Tablet is prohibited to be used when there is a change in its character.

10. Children must be used under adult supervision.

11. Please keep Yin Qiao Antidote Tablets out of the reach of children.

12. If you are using other medicines, consult your physician or pharmacist before using Yin Qiao Antidote Tablets.

5.9 Drug interactions

Drug interactions may occur when used with other drugs, consult your physician or pharmacist for details.

5.10 Remarks