There are a large number of eccrine glands in the skin of hands and feet, and eccrine glands are vigorous. The clinical manifestation is sweating, called hyperhidrosis of hands and feet. Normal physiological hands and feet will sweat, sweating is abnormal. The sweat glands of hyperhidrosis of hands and feet mainly secrete cholinergic nerves, which leads to excessive acetylcholine secretion and sweating. Drugs that inhibit cholinergic secretion are often not used for treatment, because cholinergic glands are not only exocrine glands, but also salivary glands, lacrimal glands and other glands, so not all glands secrete after using these drugs, and patients are very uncomfortable. The local treatment is as follows: 1, try to penetrate air socks and shoes; 2, you can use some drugs to inhibit sweat glands, such as drugs sold in supermarkets to remove underarm odor, or 2%-4% formaldehyde solution, 20% aluminum chloride or anhydrous ethanol; 3, sometimes emotional, sweating increases, you can hold back, or calm your mood, consciously stabilize yourself, don't be too excited, you can also reduce sweating on your hands and feet.