2. Motherwort, also known as Cnidium montanum and Cnidium montanum, is a kind of herbaceous plant, bitter, pungent, and slightly cold. Because it contains selenium and manganese and other trace elements, can be antioxidant, anti-aging, anti-fatigue and inhibit the proliferation of cancer cells, therefore, have the effect of skin care.
Effects on uterus:Motherwort decoction, ethanol extract and motherwort alkaloids have excitatory effects on the isolated uterus of rabbits, cats and other animals.
Anti-platelet aggregation and anti-thrombosis:
In vitro experiments proved that
Motherwort and its extracts have antagonistic effects on ADP-induced platelet aggregation in normal animals. In vivo experiments also proved that motherwort significantly reduced the total number of platelets in the peripheral circulation and platelets and their aggregates in the alveolar wall capillaries. Motherwort had a significant solubilizing effect on red blood clots in the pulmonary circulation of rabbits. In addition,
Motherwort also enhances cellular immunity.
It has the effect of improving coronary circulation and protecting the heart: motherwort can promote the rapid recovery of local blood flow microcirculation disorders caused by isoprenaline.
Cardiovascular effects:
Motherwort significantly increased coronary flow and slowed heart rate considerably in isolated guinea-pig hearts, in a model of isoprenaline-induced myocardial ischemia.
Motherwort was also shown to increase coronary flow and slow heart rate considerably. Intravenous motherwort preparations significantly increased coronary flow, decreased coronary resistance, slowed heart rate, and reduced output and left ventricular work in anesthetized dogs.
The effect on the respiratory center: motherwort has a direct excitatory effect, the respiratory rate and amplitude of anesthetized cats were significantly increased after intravenous injection of motherwort alkaloids, but the respiratory rate was changed from excitatory to inhibitory in large doses, and became weak and irregular. However, at high doses, the respiration was changed from excitation to inhibition, and became weak and irregular. After cutting off the nerves on both sides, the respiration was still not stimulated.
Effects on intestinal smooth muscle: A small amount of epsilonine can make the isolated intestinal tube of rabbits relax in tension and enlarge the amplitude, while a large amount of epsilonine can make the amplitude smaller and the frequency increase.
Other effects:The alkaline subcutaneous injection of epsom salts has a central inhibitory effect, the MLD is 0.4-0.6g/kg. 1mg/kg of epsom salts injected intravenously in rabbits can be seen as a significant increase in urine output. The higher concentration of epsom salts can cause hemolytic effect in rabbit blood suspension. The aqueous infusion of motherwort alkaloid was diluted 1:13-1:10 in test tubes, and had inhibitory effects on Trichoderma lucidum, Trichoderma lanuginosa, S. epidermidis red, and Nucella stellata. The decoction of motherwort has inhibitory effect on Escherichia coli and Shigella dysentery bacillus by plate paper method.
Precautions when taking motherwort:
It should not be used with epinephrine. Motherwort has antihypertensive effect, can reduce or even reverse the effect of adrenaline.
It should not be used with isoprenaline. Motherwort increases coronary flow, slows heart rate, and can antagonize the cardiac stimulatory effects of the beta-agonist isoprenaline.
It should not be used with atropine. It can weaken the antihypertensive effect of motherwort.
In addition, modern research has found that the active ingredients of motherwort have an excitatory effect on the uterus and can contract the uterus, so it should be avoided during pregnancy. At present, there are many forms of motherwort on the market, such as motherwort cream, motherwort granules, motherwort tablets, etc. The active ingredients of various medicines are different, so patients should be under the guidance of a doctor, depending on the specific medicines and with reference to changes in the condition.