Hand, foot and mouth disease (HFMD) is a common infectious disease caused by various human enteroviruses, mainly occurring in infants. Most children have mild symptoms, mainly manifested as fever and rash or herpes on hands, feet and mouth. A small number of children may have central nervous system and respiratory system damage, which may lead to aseptic meningitis, encephalitis, acute flaccid paralysis, neurogenic pulmonary edema and myocarditis. Some seriously ill children are prone to death.

The pathogens causing hand, foot and mouth disease are mainly Coxsackie virus types 2, 4, 5, 7, 9, 10 and 16 in group A and 1 2, 3, 4 and 5 in group B; Enterovirus 71; Echovirus, etc. Enterovirus 7 1 and coxsackievirus A 16 are more common.

Enterovirus is suitable for living and spreading in hot and humid environment, and it is insensitive to ether and dechlorocholate. 75% alcohol and 5% lysol cannot be inactivated, but it is sensitive to ultraviolet light and dryness. Various oxidants (potassium permanganate, bleaching powder, etc. ), formaldehyde and iodine can inactivate viruses. The virus can be quickly inactivated at 50℃, but the bivalent cation environment with the concentration of 1mol can improve the resistance of the virus to thermal inactivation. The virus can survive at 4℃ 1 year, at -20℃ for a long time, and in the external environment for a long time.