1 Effect on smooth muscle The soybean glycosides in Pueraria Mirifica have an anti-acetylcholine effect and can significantly contract smooth muscle, which is considered to be the main component of the antispasmodic effect of Pueraria Mirifica. 2 Effects on coronary circulation Pueraria lobata decoction, alcohol extract, total flavonoids and Puerarin have obvious coronary vasodilating effects, which can increase coronary blood flow and reduce vascular resistance. 3 Effects on myocardial infarction and arrhythmia Pueraria lobata alcoholic extract, soybean glycosides and Puerarin have obvious effects against the arrhythmia induced by aconitine and barium chloride, Puerarin can also significantly shorten the time of chloroasthene, adrenaline-induced arrhythmia in rabbits, Puerarin can significantly reduce the scope of myocardial infarction, and it is considered to be a kind of β-adrenoceptor blocking agent. 4 Effects on cardiac function and myocardial metabolism Pueraria Mirifica total flavonoids and Puerarin can slow down the heart rate, reduce the total peripheral resistance of the heart, reduce myocardial oxygen consumption; improve the efficiency of myocardial work . Puerarin can also significantly reduce ischemia-induced myocardial lactate production and improve the metabolism of infarcted myocardium. 5 Effects on blood pressure and peripheral vascular Pueraria Mirifica total kudzu and Puerarin can make plasma renin activity and angiotensin significantly reduced, blood pressure decreased. Puerarin has a significant improvement effect on microcirculation disorders, mainly manifested as an increase in the amplitude of microvascular movement and improve the local microblood flow; Pueraria Mirifica total flavonoids have a significant dilation of cerebral blood vessels, improve cerebral microcirculation and peripheral circulation. It is reported that Pueraria Mirifica can also improve the blockage of retinal vascular terminal units, thus improving visual function. 6 Inhibition of platelet aggregation Puerarin can inhibit adenosine diphosphate (ADP)-induced and 5-HT (5-hydroxytryptamine) and ADP-induced platelet aggregation in humans and animals; in addition, Puerarin can significantly inhibit the release of 5-HT in platelets induced by thrombin, with antithrombotic effects. 7 Hypoglycemic effect Puerarin can counteract the blood glucose-raising effect of adrenaline, and has certain hypoglycemic ability. 8 Effect on body temperature Pueraria Mirifica has a long-lasting and obvious hypothermic effect on endotoxin-induced elevation of body temperature, and is commonly used in the clinic for external fever. 9 Effect on memory The total flavonoids and alcoholic extracts of Pueraria Mirifica can increase the content of acetylcholine in the cerebral cortex and hippocampus of rats, and reduce the activity of hippocampal acetylcholine transferase, and counteract the memory acquisition disorder of rats by the effect of dongleine, which suggests that Pueraria Mirifica has the ability to improve the learning memory to a certain extent. 10 Toxicity and side effects The LD50 of total flavonoids of Pueraria Mirifica is as high as (0.738-1.00) g/kg, and the clinical dosage of Pueraria Mirifica is as high as (45-60) g/d, and no toxicity and side effects have been seen. Shi Jilan et al. conducted short-term mutagenicity and teratogenicity tests on the injections of Pueraria Mirifica, and the results showed that there was no mutagenicity and teratogenicity. This shows that Pueraria Mirifica is a low toxicity, high safety of wild plants, can be expected to become a new medicinal edible plants. Clinical application of Pueraria Mirifica The medicinal use of Pueraria Mirifica was first published in Shennong Ben Cao Jing (Classic of the Materia Medica of the Divine Husbandman), which says, "Pueraria Mirifica is sweet in flavor and flat in nature. Main thirst, body fever, vomiting, paralysis, up the yin qi, detoxification". Famous Doctor's Record", "Pueraria Mirifica is non-toxic, treatment of colds, stroke headache, relief of muscles published sweating, open the coupling, treatment of gold sores, pain relief of coercive wind pain. Raw root juice: cold. Cure thirst, cold and fever. Leaves: main gold sores to stop bleeding. Flowers: the main elimination of alcohol". Since then, successive generations of materia medica and Chinese medicine books have been recorded. In recent times, the clinical application of Pueraria Mirifica is very extensive, and the diseases that can be treated at present are: (1) angina pectoris of coronary heart disease; (2) pulmonary heart disease; (3) cerebral arteriosclerosis and cerebral infarction; (4) hypertension; (5) diabetes mellitus; (6) retinal obstruction; (7) sudden deafness; (8) vascular-neurogenic headache; (9) viral myocarditis; (10) neurogenic deafness and vertigo; (11) tardive dyskinesia; (12) tardive dyskinesia; (13) tardive dyskinesia; and (14) tardive dyskinesia. movement disorders; (12) ureteral stones; (13) allergic skin diseases; and (14) gouty arthritis

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