Efficacy and function of Siwu decoction: regulating menstruation, relieving pain, nourishing blood and relaxing muscles and tendons
Siwu decoction has the function of regulating menstruation and relieving pain, which can help to remove blood stasis and promote blood circulation, so that menstrual blood can be eliminated smoothly; In addition, Siwu decoction can supplement the iron needed by human body to reduce anemia, dizziness and poor menstrual blood during menstrual cramps.
Improve sub-health symptoms
People who sit in the office for a long time are prone to sub-health symptoms such as gas color difference, qi deficiency and fatigue due to excessive work pressure and lack of exercise. In this case, taking some Siwutang in moderation can effectively improve sub-health symptoms.
Prevent skin aging
Most of the medicinal materials in Siwutang are warm-nourishing blood tonic, so it is helpful to get into the habit of taking Siwutang regularly, which will help to smooth blood, avoid cold hands and feet, make your face more ruddy, keep your skin moist and smooth, and delay the aging of your body function.
Moistening dryness and nourishing lung
The dry weather in autumn and winter is prone to allergic symptoms such as itchy skin and dry throat. At this time, the rehmannia root in Siwutang is replaced by rehmannia root, which can be taken with Ophiopogon japonicus and Asparagus, which can play a role in moistening dryness and nourishing the lungs.
Clearing heart and reducing fire
When the weather is hot and humid, the human body will have a strong heart fire, which will often lead to early menstruation, irritability, night sweats and poor sleep quality. At this time, increasing the weight of Paeonia lactiflora in Siwu Decoction, or adding Huang Cen and bamboo leaves as appropriate, can help clear the heart and reduce internal heat.
Reinforcing body resistance
In winter, when the weather is cold, the human body's meridians begin to be in semi-dormancy, the activity decreases, and the resistance decreases. Many women begin to feel cold and dysmenorrhea. At this time, it is very important to warm the yang and tonify the kidney. If you drink Siwutang, you should increase the proportion of Angelica sinensis, and add cassia twig, dodder and Morinda officinalis as appropriate.
What side effects does Siwutang have?
1. Siwu decoction, as a tonic, has warm and dry properties. Therefore, for some people with hot constitution or internal heat, taking Siwutang is easy to get angry and get acne.
2. Rehmannia glutinosa and Angelica sinensis are easy to cause diarrhea for people with poor gastrointestinal function.
3. Taking Siwutang often makes you feel thirsty.
Need to take siwu decoction
1. Reduce the dosage of Ligusticum chuanxiong for blood fever;
2. Rehmannia glutinosa should be used for deficiency-cold constitution, and rehmannia glutinosa should be used for heat constitution;
3. When it is necessary to supplement and clear heat, the raw land and the cultivated land are half;
4. Dry mouth should add Scrophularia;
5. If you love fire and acne symptoms, you need to take Qinlian Siwu Decoction, which has the function of cooling the upper part and tonifying the lower part.
matters need attention
Pregnant women should use it with caution. Menstruation due to yin deficiency and blood heat, fetal movement and red leakage are not suitable for this prescription.
Pharmacological action of Siwu decoction1.Correcting anemia;
Intraperitoneal injection of methylcellulose (MC) into rats or mice can cause experimental anemia. There are splenomegaly and nephropathy, and the animal mortality rate is high. The n-butanol extract of this prescription can reduce the mortality rate of the model mice, and the hematological observation also shows that it has anti-anemia effect, but it has no effect on the model rats. The water extract of this medicine has only a slight inhibitory effect on anemia caused by phenylhydrazine. For acute hemorrhagic anemia in mice caused by bloodletting, after oral administration of this medicine, it was found that the ratio of granulocyte to erythrocyte, the percentage of nucleated cells and the morphology and quantity of bone marrow staining could improve the hematopoietic function of bone marrow and promote the recovery of anemia, and the effect of Sijunzi Decoction, a simple prescription for invigorating qi, was weaker than this prescription. It also has a certain therapeutic effect on rats with hemolytic anemia, but its effect is weaker than Sijunzi Decoction. This prescription has increased the visible blood components such as red blood cells, hemoglobin and reticulocytes in experimental acute hemorrhagic anemia animals to varying degrees, with the increase of hemoglobin being significant.
2. Anti-radiation damage:
Before giving lethal dose of radiation to normal mice, intraperitoneal injection of 200mg/kg methanol extract of Siwutang can obtain good protective effect. However, the prescription has no such effect after radiation irradiation. This protective effect is dependent on Chuanxiong, and Angelica sinensis and Paeonia lactiflora have auxiliary effects.
3. Anti-platelet aggregation and anti-thrombosis:
Siwu decoction has obvious inhibitory effect on ADP-induced platelet aggregation in rabbits, which is realized by increasing the concentration of AMP and the content of ferulic acid in platelets. In the experiment of thrombus outside antibody, it was observed that there was no thrombus in Siwutang group, while the thrombus length (mm), wet weight (mg) and dry weight (mg) in control group were 0.2 0.61,77.814.51and 35.7 4.69 respectively.
4. Anti-hypoxia:
In the experiments of mice's overall hypoxia under normal pressure, myocardial hypoxia caused by isoproterenol, cerebral hypoxia caused by ligation of common carotid artery and cell hypoxia caused by sodium nitrite poisoning, Siwutang group (0. 1ml/ 10g body weight of Siwutang), The survival time (minutes) were 7.571.68, 6.22 0.74, 4.671.35, 52.5 4.1respectively, while the survival time (minutes) of the control group (intraperitoneal injection of the same amount of normal saline) was. It is proved that Siwu decoction has a good anti-hypoxia effect.
5. Anti-free radical damage:
After being stimulated by O3, young rats can produce physical strength, cold resistance and hypoxia tolerance, which are similar to the decline of physiological functions of old animals, and Siwu Decoction can obviously improve the above indexes of aging models. The activity of MAO-B in the brain of mice in the experimental model group increased, showing biochemical changes consistent with those of aged animals. The inhibition rate of chemiluminescence in serum of mice in the treatment group increased, and SOD activity increased; The content of lipid peroxide in plasma, brain and liver tissue and the activity of MAO-B in brain tissue decreased. There is a dose-effect relationship between different doses.
6. Inhibition of granulation proliferation:
Adjuvant granulation sac was made on the back of ddy mice, and four fields (50-200mg/kg) were administered intraperitoneally. It was found that the wet weight of granulation and the amount of new blood vessels could be inhibited in a dose-dependent manner, and the maximum inhibition rate was 40%. The inhibitory effect of Siwu decoction on granuloma proliferation is mainly played by Chuanxiong and Angelica sinensis, which constitute crude drugs, and its mechanism of action is to inhibit the proliferation of vascular smooth muscle cells. The proliferation of cultured vascular smooth muscle cells was promoted by 10% calf serum. Siwu decoction (4-500μg/ml) was dose-dependent, and the maximum inhibition rate was 46%.
7. Inhibition of uterine muscle activity:
Angelica sinensis, Radix Paeoniae Alba, Rhizoma Ligustici Chuanxiong, Fructus Lycii, Rhizoma Cyperi, and Radix Glycyrrhizae were used as the basic prescription. When the concentration was 1× 10-2(g/ml), the spontaneous movement of rat uterus was inhibited, the frequency was obviously reduced, and the muscle tension was slightly decreased. The average inhibition rate of the frequency for 5 minutes before and after administration was 53.3%. 2.5ml/kg(5g/kg) of this prescription was given to duodenum, which obviously inhibited the frequency of spontaneous uterine movement in rabbits. After 60-70 minutes, the average frequency inhibition rate was 42%, and the muscle tension did not change obviously. However, this prescription has no effect on the contraction amplitude of spontaneous movement of rat uterus in vitro and rabbit uterus in vivo. When the concentration of this prescription is 1× 10-2(g/ml), it can weaken the uterine contraction reaction caused by the concentration of prostaglandin F2α of 2.5× 10-7(g/ml), and the muscle tension is slightly increased and the frequency is reduced.
8. Regulating immune function:
Through lymphocyte transformation test and active spot test, it is shown that this prescription has obvious promoting effect on cellular immune response. When 4× 10-7/ml spleen cell suspension was added with 2μg/mlHC and 2mg/ml Siwu decoction, the OD values were 0.326 0.037 and 0.696 0.159, respectively, which showed that our prescription could resist the inhibitory effect of HC on lymphocyte proliferation. It has certain effects in resisting delayed skin hypersensitivity (DCH) in mice inhibited by CY, hemolysin production in mice sensitized by sheep red blood cells (SRBC) inhibited by CY, and carbon clearance rate in mice inhibited by CY.
9. Supplement trace elements:
The contents of Cu, Zn, Mn and Fe in this prescription were determined by flame atomic absorption spectrometry, and Ni, Cd, Po and Cr were determined by graphite furnace atomic absorption spectrometry. Most of these trace elements are related to hematopoiesis.
10. supplement phospholipids and vitamins:
The content of total phospholipids in Siwu decoction was 0.025mg/g by molybdenum blue colorimetry, and vitamin C6 1.20mg/g and folic acid 0.2 12mg/g by HPLC.