On November 29, 1984, a research group led by Prof. Hiroaki Namba, Ph.D., of the Japan Institute of Oncology and an internationally renowned oncology authority, was granted a patent for the organic bio-extraction of maitake polysaccharides under the patent No. JP 59210901.

In 1986, the world's first maitake D-component nutrient preparation, which is the strongest anticancer agent among the fungus medicines in the world, was extracted in Japan. It was used for clinical assistance in the treatment of several types of tumors.

Since 1990, Maitake Difusan has been the subject of research at several prestigious U.S. oncology institutes and university hospitals for the purpose of observing and certifying its effects on patients with a wide range of different tumors.

On February 1, 1998, the U.S. FDA broke with its usual practice and allowed Maitake Essence Drops (a 30% professional-grade extract) to enter directly into a Phase II clinical study (IND No. 54589) in advanced breast and prostate cancers.

On December 29, 1998, Maitake Difusan was awarded the U.S. National Patent No. US 5854404.

In May 2004, the International Cancer Symposium was held in Tokyo, and Maitake Difusan became the first choice of the alternative medicine for "alternative oncology therapies".

In May 2005, Memorial Sloan-Kettering Center in New York, the world's leading authority in the field of anti-tumor therapy, formally included maitake Difusan in its list of new drugs to assist in the treatment of advanced breast cancer.

It was verified that the applicant for "On February 1, 1998, the U.S. FDA broke with its usual practice and allowed Dancing Mushroom Essence Drops, a professional-grade extract at 30%, to be entered directly into a Phase II clinical study (IND No. 54589) in advanced breast and prostate cancer" was Mack Health Foods USA.

Maitake Standardized Extract-Pro Maitake D-fraction (Grifron®-Pro Maitake D-fraction®) is a flagship product of Mack Health Foods, Inc. in '95, and is the only proven Maitake Standardized Extract-immunity-boosting end-product. It is the only proven standardized extract of Maitake mushrooms - the ultimate in immune enhancement.