Uric acid is the final product of purine metabolism and an important ion in human body. Abnormal uric acid level will affect many organ functions. Hyperuricemia is an independent risk factor for cardiovascular disease and chronic kidney disease. Common causes of hyperuricemia include the following. First of all, genetic factors are caused by mutations in various purine metabolizing enzymes. Second, the food factor, common is high purine food intake too much, high purine content of food, including animal offal, seafood, beer and fructose content of food, alcohol and so on. Third, hyperuricemia caused by drugs. Commonly used drugs include diuretics, cyclosporine or tacrolimus and low-dose aspirin. 4. Diseases and states related to hyperuricemia, including renal failure, metabolic syndrome, diabetes, untreated hypertension and after strenuous exercise.