Can gout occur while taking febuxostat? Is it very possible? What should I do if gout occurs while taking febuxostat? How to prevent gout while taking the medicine. Today I will give you a brief introduction - why do joint pain occur while taking febuxostat?
Febuxostat is a newer uric acid-lowering drug, but its mechanism of action is not new. Like allopurinol, febuxostat is a uric acid production inhibitor that inhibits xanthine oxidation. Enzyme activity reduces the production of uric acid in the body, thereby achieving the effect of lowering uric acid.
Since it inhibits the production of uric acid, why does it cause joint pain? For patients with hyperuricemia, the concentration of uric acid increases, and slightly soluble uric acid easily forms monourate crystals. Whether there is no gout attack or in the intermittent period of gout, it does not mean that there are no monourate crystals in the joints. When taking febuxostat to lower uric acid, the concentration of urate in the blood will decrease, which will induce Dissolve the urate crystals deposited in the joint cavity. When they dissolve, they do not dissolve all at once, but first dissolve into finer crystal particles. These finer crystal particles stimulate the joints, produce inflammatory reactions, and cause pain. , redness and swelling, etc. This is a gout attack while taking medicine, sometimes also called "little gout". What should I do if I have joint pain while taking febuxostat?
What should I do if gout occurs while taking Febuxostat? Of course, the first thing to do is to take medication to control pain. Colchicine, celecoxib and other non-steroidal anti-inflammatory drugs, and glucocorticoid drugs are all drugs that can be selected to control inflammatory pain and reduce inflammatory stimulation. Improving pain symptoms and providing symptomatic treatment are conventional treatments for gout caused by taking uric acid-lowering drugs.
Should I take febuxostat during gout? You can continue to take it. Although we generally say that uric acid-lowering treatment is not recommended during an acute attack of gout, this is true if you are not taking uric acid-lowering drugs. For those who develop gout while taking uric acid-lowering drugs, During the process of controlling pain, you can continue to take uric acid-lowering drugs. How to prevent gout while taking febuxostat?
If you want to reduce the chance of gout attacks while taking febuxostat, the first thing you should do is one word - slow down. Don't rush to lower uric acid. You should start with a low dose and take it regularly. Monitor the decline of uric acid. If you take a low dose for a period of time and the uric acid control is still not ideal, if your body tolerates it, take more and slowly lower the uric acid. This will reduce the chance of gout during the uric acid lowering period and make it easier. Easily improves body tolerance.
One more thing to note is to drink more water. Usually when taking drugs that promote uric acid excretion, such as benzbromarone, we say you must drink more water. In fact, when taking febux During this period, drinking more water and urinating more will also help reduce the risk of gout while taking the medicine. Some experts recommend drinking more pure milk while taking febuxostat, which is of course also possible.