The mechanism of colchicine:
1, inhibitory effect: colchicine can be combined with microtubule protein dimer, preventing the conversion of microtubule protein, so that the cell stops in the middle of mitosis, thus leading to cell death.
2, anti-inflammatory effect: colchicine by interfering with lysosomal degranulation to reduce neutrophil activity, adhesion and chemotaxis, inhibit the granulocytes to the inflammatory region of the wandering, so as to play an anti-inflammatory role.
3, inhibitory effect: animal experiments found that colchicine can reduce the mortality rate of toxic hepatic necrosis in male rats, to prevent carbon tetrachloride-induced hepatic fibrosis in rats and improve their liver function, domestic experiments have also confirmed that colchicine can reduce the formation of hepatic collagen fibers, reduce hepatic fibrosis.
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Expanded Information: Mitosis: Colchicine inhibits mitosis, destroying the spindle and stalling chromosomes at mid-division. This abnormal division caused by colchicine is called colchicine mitosis (C-mitosis). In such mitosis, although the chromosomes split longitudinally, the cell does not divide and cannot form two daughter cells, thus doubling the chromosomes. Since 1937, the American scholar Blakeslee (A.F. Blakeslee), etc., with colchicine doubled the number of chromosomes in plants such as mandrake and other success, colchicine has been widely used in cytology, genetics research and plant breeding work. For example: wheat and rye cross, the hybrid is sterile, with colchicine treatment, doubling the chromosomes, can become fertile heterozygous octoploid rye, planted in the alpine region of Yunnan and Guizhou, the yield and quality is better than wheat and rye. In the 1950s, Japan used colchicine to treat general sugar beet to get tetraploid, the latter planted with diploid varieties, harvested from tetraploid plants to triploid seeds. Promote the cultivation of triploid sugar beet, obtained a great economic benefits. /baike.baidu.com/item/%E7%A7%8B%E6%B0%B4%E4%BB%99%E7%A2%B1?fromtitle=%E7%A7%8B%E6%B0%B4%E4%BB%99%E7%B4%A0&fromid=745321 #3 "target="_blank "title="Web Link">Baidu Encyclopedia - Colchicine