Currently alkaline phosphatase (ALP) Alkaline phosphatase (ALP) refers to a group of enzymes with very low substrate specificity that can hydrolyze many phosphate monoester compounds in an alkaline environment, requiring magnesium and manganese ions as activators. In recent years, it has been suggested that the real role of ALP is to transfer the phosphate group of the substrate to another compound containing a hydroxyl group, and it is possible that ethanolamine phosphate is the substrate for ALP action in vivo. After a high-fat meal, serum ALP activity is elevated, especially in the blood type O or B secretion type (saliva can be secreted blood type antigen) population is more prominent, increased ALP is mostly for the small intestine ALP.

The measurement is mainly used for the differential diagnosis of jaundice, jaundice, jaundice, serum ALP is often significantly higher in the early stage of obstructive jaundice, and even up to the upper limit of the value of the normal 10-15 times in the case of complete obstructive jaundice, 80% of the cases in the blood of jaundice, the blood of jaundice, jaundice, jaundice, jaundice, jaundice and jaundice. In cases of complete obstructive jaundice, 80% of the cases have ALP more than 5 times the upper limit of normal. Generally speaking, when serum ALP is persistently lower than 2 times of the upper limit of normal value, the possibility of obstructive jaundice is small, and ALP is mildly elevated in hepatic jaundice, generally not more than 2-3 times of the upper limit of normal value, and ALP is elevated in about half of the cases of primary hepatocellular carcinoma, and the extent of the elevation is often more obvious, and can even be up to 15-20 times of the upper limit of normal value. If ALP is found to be elevated in the blood of people without jaundice liver disease, they should be alerted to the possibility of liver cancer.

ALP elevation can also be seen in other diseases, such as acute and chronic pancreatitis, chronic renal failure, intestinal infarction, pulmonary infarction and other diseases, but there is not much clinical value, some drugs such as progesterone, estrogen, placental albumin, etc. can also cause ALP elevation in the blood.