Alkaline phosphatase (ALP) is widely distributed in various organs and organs of human body, among which the liver is the most, followed by kidney, bone, intestine, placenta and other tissues.
ALP in serum mainly comes from liver and bone. Most of the serum of growing children comes from osteoblasts and growing osteochondral cells, and a small amount comes from liver.
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2) Clinical significance
Clinical determination of ALP is mainly used for the diagnosis and differential diagnosis of diseases of bone, hepatobiliary system, especially the differential diagnosis of jaundice. For unexplained high ALP serum level, isoenzymes can be determined to help clarify its organ source.
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① Physiological increase
During physiological skeletal development, the activity of alkaline phosphatase in children is 2 times higher than that in normal people1-. Teenagers in the growing period and after eating foods with high fat content can all rise.
② Pathological elevation
A. Bone diseases such as rickets and rickets.
B. Hepatobiliary diseases such as extrahepatic biliary obstruction and capillary bile duct hepatitis.
C. Other diseases such as hyperparathyroidism.
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Love tip: Don't be too nervous when you find that transaminase has increased, but you should pay enough attention to it. You should correct your schedule and eating habits in time and go to the hospital for re-examination after your health is normal.
If you are satisfied with the above answers, please don't live up to my kindness and adopt them as answers in time.