Because the tip of keratin plug stimulates nerve endings in dermal papilla, it will cause severe pain when standing and walking. In addition, if patients often wear tight narrow shoes or have deformed feet, they can also cause local friction and pressure on the soles of their feet, resulting in keratin thickening and corns. Clinically, it needs to be differentiated from plantar warts and toes. The plantar wart is infected by human papillomavirus, which leads to nipple-like keratin hyperplasia on its surface. There are black bleeding spots in the middle of dermatoglyphics, and the squeezing pain is obvious. Toe-toe, irregular keratotic patches or strips, smooth surface, unclear edge, generally no pain.