Dispersible tablets refer to tablets that can disintegrate rapidly and disperse evenly in water. They can be taken orally after being dispersed with water, or they can be sucked or swallowed in the mouth. Compared with ordinary tablets, dispersible tablets are not affected by physiological environment, and have the characteristics of rapid dispersion and high bioavailability. At the same time, because of its uniform dispersion, it avoids the adverse reaction caused by excessive local concentration caused by instantaneous local release of tablets in vivo. Compared with oral liquid dosage form, it has the same dispersion effect as suspension, and avoids the shortcomings of poor stability and inconvenient storage and transportation of suspension preparation. Abroad, dispersible tablets were listed in1980s. British Pharmacopoeia 1980 edition contains dispersible tablets. European Pharmacopoeia 2003 Edition. At present, National Medical Products Administration, China has approved many varieties of dispersible tablets to enter clinical research and market, such as Gynostemma pentaphyllum total glycoside dispersible tablets developed by Shanxi Yabao Pharmaceutical Group and amoxicillin dispersible tablets produced by Huatai Company of North China Pharmaceutical Group.
At present, many varieties of dispersible tablets have been used in clinic at home and abroad. According to the clinic, the dispersible tablets were officially collected under the tablet. According to the data provided, the curative effect of dispersible tablets of some drugs is better than that of ordinary tablets. Because of its convenient use, it is especially suitable for children, the elderly and patients with dysphagia. .
Common name cefaclor capsules
previous name
English name CEFACLOR CAPSULES
Pinyin name TOUBAO KELUO JIAONANG
Drug categories cephalosporins and carbapenems
Character capsule, the content is white to light yellow powder.
Pharmacological, toxicological and antibacterial drugs. The β -lactamase produced by Staphylococcus aureus is stable, so it has strong antibacterial effect on gram-positive bacteria. β -lactamase produced by gram-negative bacteria is unstable, so it has weak effect on gram-negative bacteria and is ineffective on Pseudomonas aeruginosa and anaerobic bacteria.
Pharmacokinetics According to the literature, cefaclor is rapidly absorbed from the intestine after oral administration and distributed in the whole body. The peak plasma concentration of 0.5g capsule was 16mg/L, the peak time was about 0.5 hours, and the clearance half-life was 0.6 ~ 0.9 hours. After taking the medicine, about 77% of the original medicine was excreted by urine within 8 hours.
Indications are mainly used for respiratory system, urinary system, otorhinolaryngology, skin and soft tissue infections caused by sensitive bacteria.
Administration and dosage: 0.25g for adults once, three times a day. The dose of patients with severe infection can be doubled, but the total daily dose should not exceed 4.0g. Or follow the doctor's advice.
Adverse reactions 1. Gastrointestinal tract: diarrhea, stomach discomfort, nausea and vomiting. 2. Allergic reaction: urticaria, rash, eosinophilia, pruritus vulvae. 3. Others: slight increase of aminotransferase, plasma urea nitrogen (BUN) and creatinine (Cr), proteinuria, cast, etc.
Contraindications are prohibited for those who are allergic to cephalosporins.
Precautions should be used with caution for those who are allergic to penicillin and severely damaged renal function.
Pregnant women and lactating women use drugs with caution.
Children's medication
Medication for elderly patients
Drug interaction is not clear.
overdose
Store in a dark and dry place.
package
term of validity
major constituent
Common name cefaclor
Chemical name (6R,7R)-7-[(R)-2- amino -2- phenylacetylamino ]-3- chloro -8- oxo -5- thio-1- azabicyclo [4.2.0] octyl -2- ene -2- carboxylic acid monohydrate.
Pinyin name TOUBAOKELUO
English name CEFACLOR
CAS No. 53994-73-3
constitutional formula
The molecular formula is c15h14cln3o4s H2O.
Molecular weight 385.82
Gauge 0.25g (calculated according to C 15H 14CIN3O4S)