The extraction of heparin sodium comes from the mucosa of porcine small intestine, through the 2709 protease enzyme digestion to get heparin solution, and then add sodium chloride and elevate the temperature so that the porcine small intestine mucosa in the coagulation of animal proteins, so that the generation of heparin sodium is easy to carry out the ion exchange; the use of dilute sodium chloride solution washed by a strong alkaline ion exchange resin and then eluted with a high concentration of sodium chloride solution, the eluted heparin sodium precipitated in the alcohol solution, and dried to produce crude heparin sodium; and then acidification to remove acid heteroproteins, and then two oxidation refinement operation to produce the product unit potency per unit of pollution. After the elution, heparin sodium is precipitated in alcohol solution and dried to obtain crude heparin sodium; then the crude heparin sodium is acidified to remove acidic heteroprotein, and then two oxidation refining operations are carried out, and the unit potency of the product is 140~150 international units per milligram or more, and the product is aseptic, non-pyrogenic product, especially in the process of preparation of no wastewater pollution of the environment. Steps: soak the resin after reuse in water, fish out and filter dry; add the resin after filter drying into the brine with the specific gravity of 23 degrees to soak, filter to get the filtrate, keep stirring during the soaking, and the amount of brine added is 0.7 times of that of the resin; add the filtrate into the brine with the specific gravity of 25 degrees to soak, filter to get the filtrate, keep stirring during the soaking, and the amount of brine added is 0.7 times of that of the resin; add the filtrate to the brine, keep stirring, and the amount of brine added is 0.7 times of that of the resin; and add the filtrate to the brine. 0.7 times; the filtrate A and filtrate B mixed, add 85 degrees of alcohol until the filtrate alcohol for 35 degrees, get the white precipitate for sodium heparin; due to take the water immersion, so that the resin is fully expanded, and two different concentrations of brine immersion, so that the resin in the adsorption of sodium heparin to fully elute out, not only to increase the amount of heparin sodium extracted, but also improve the resin's ability to repeat the adsorption

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