If Amomum villosum is crushed, it should be taken later. Whether some drugs are taken later or not is related to their uses. If rhubarb is used for diarrhea, it needs to be used later; If it is used for purging fire, detoxicating, promoting blood circulation, removing blood stasis, promoting gallbladder function and eliminating jaundice, it can't be used later, but it needs to be decocted with group drugs. Modern research shows that anthracene glycoside is the main component of rhubarb diarrhea, among which sennoside A has the strongest effect, which is easy to dissolve in water and is often destroyed after long-term decoction. Rhubarb also contains tannin (with astringent effect), which can be dissolved after long-term decoction, so it has no purgative effect, but constipation. Uncaria rhynchophylla is used for lowering blood pressure, because the rhynchophylline can excite the respiratory center, inhibit the vascular inhibition center, dilate peripheral blood vessels, and lower blood pressure. However, after decocting for more than 2 minutes, the rhynchophylline content was destroyed, and the hypotensive effect decreased. However, long-term decoction has sedative effect and can be used to treat convulsions.

The medicine should be soaked in cold water for 2 minutes before being decocted.