Pufferfish is a highly toxic fish, and its processing and sales must be specially approved by the health department. Most catering units are not allowed to process and sell puffer fish without permission, and consumers should actively refuse to eat puffer fish.

The puffer fish contains a tetrodotoxin and tetrodotoxin, which are two highly toxic substances. According to the determination, its toxicity is equivalent to 1250 times of the dramatic drug sodium cyanide, and it is one of the most toxic non-proteins found in nature so far. Tetrodotoxin is mainly concentrated in ovary, liver and blood, followed by eyes, gills and skin. The muscles of individual species also contain toxins. The chemical properties of this toxin are relatively stable, and it can not be destroyed quickly after frying, boiling, salting and sun exposure, so the mortality rate of human and animal poisoning is extremely high. After eating, once the symptoms of puffer fish poisoning are found, they should be sent to the hospital immediately for rescue. Subcutaneous injection or intravenous injection of baking soda solution can be used to quickly detoxify. Adrenaline, trichosanthin, camphor and caffeine can also be injected separately, and the effect is also ideal.