Pharmaceutical companies clean plant surfaces can be used when necessary, chemical, physical or other means of regular cleaning and disinfection, kill pathogenic microorganisms, so that the total amount of microorganisms controlled in the clean environment within the scope of the daily monitoring, in order to prevent microbial impact on the environment of the production plant may be and pollution. Commonly used sterilization methods for clean environments include: formaldehyde fumigation, ozone fumigation, lactic acid fumigation, hydrogen peroxide fumigation and other disinfectant fumigation. Each sterilization method has its own specific scope of application, and the sterilization process must be consistent with the requirements of registration approval and should be validated. Production should be based on the specific circumstances of the optimal choice of disinfection to ensure that the clean environment to meet the specified requirements. 1 cleaners and disinfectants requirements Cleaners should have high efficiency, environmental protection, no residue, water-soluble, clear concentration or configuration of simple features. Suppliers should have professional qualifications. Each of the smallest packaging units are clearly marked on the production date and expiration date. The disinfectant should have the characteristics of high efficiency, environmental protection, less residue, strong water solubility and so on. Use disinfectants that meet the requirements of "Disinfection Management Measures" issued by the Ministry of Health, and rotate and alternate them every month to prevent microorganisms from developing tolerance. 2 Cleaning standard By cleaning the clean plant requires all cleaning items to be dust-free, no traces, no shedding material and neat. No dust: refers to the wall, the surface of the ground facilities without dust, dust. No trace: refers to the ground, walls, facilities, no construction without traces, no traces of traffic on the ground. No shedding material: refers to no fiber, wallpaper and other shedding material. Tidy: refers to the cleaning process in an organized manner, cleaning site, the use of their own clean utensils, neatly placed. 3 cleaning, disinfection operations ① develop standard operating procedures for the preparation of disinfectants, disinfectants should be used on-site preparation. ② for different disinfection objects to develop appropriate cleaning, disinfection methods and frequency. Cleaning, disinfection objects including walls, floor equipment, floor drains, sinks, air conditioning air vents. ③ In the cleaning area, after cleaning a production room, used mops, washing carts and other cleaning tools need to be cleaned before the next production room can be cleaned. ④ Records should be made in a timely manner after cleaning and disinfection work is completed. ⑤ The effectiveness of the cleaning and disinfection methods shall be evaluated through data analysis of quarterly and annual environmental monitoring reports.