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In different individuals with α -thalassemia, the phenotype is different due to the different number of gene deletions: ② A couple has severe anemia.
The mild genotype is AaBB or AABb, that is, one gene is missing.

Moderate patients are AaBb, that is, two deletions.

Serious Aabb or aaBb is short of three.

What is missing is expressed by recessive genes.

Because the couple gave birth to severe children, that is, three children were missing, so the genotype of the couple is AaBb*AaBb or AaBb*AABb(AaBB) phenotype: both are moderate or one is moderate and the other is mild.

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