Causes of high apolipoprotein b
The causes of high apolipoprotein B are usually physiological and pathological. Physiological reasons are mainly due to excessive intake of protein, which leads to excessive accumulation of lipid substances in the body, leading to the increase of apolipoprotein B; Of course, some diseases, such as hyperlipoproteinemia, myocardial infarction, diabetes, hepatitis and so on. It can also lead to the increase of apolipoprotein B. Therefore, when apolipoprotein B is high, it is necessary to find out the reason and treat it as soon as possible. Just pay attention to the daily care caused by physiological reasons and adjust your diet. If it is caused by pathological reasons, it is necessary to treat it as soon as possible.
Introduction of apolipoprotein b
Apolipoprotein (apo) is the protein in plasma lipoprotein, and its basic function is to carry lipids.
Because of the different amino acid composition, apoB can be divided into the following subclasses: apoB48 and apoB 100. ApoB48 is one of the apolipoproteins of chylomicrons. ApoB 100 is one of the apolipoproteins of very low density lipoprotein (VLDL) and low density lipoprotein (LDL).
Apolipoprotein B exists on the surface of low-density lipoprotein, and cells recognize and absorb LDL mainly by identifying the reason of high apolipoprotein B. Therefore, when apolipoprotein B is elevated, even if the LDL level is normal, the incidence of coronary heart disease can be increased.
The protein part of lipoprotein is called apolipoprotein (apo). Apolipoprotein has an important physiological function in lipoprotein metabolism. Apo is named after ABC. There are many species found at present, which are generally divided into 5 ~ 7 categories. Mainly determine ApoAI and ApoB.
ApoAI is mainly synthesized by liver, but also by small intestine. It is the main structural protein of high density lipoprotein cholesterol (HDL-CHOL), accounting for 60% ~ 70% of the total protein of HDL-CHOL. The determination of ApoAI can directly reflect the level of HDL-CHOL.
ApoB is also synthesized by liver, and it is the main structural protein of low density lipoprotein cholesterol (LDL-CHOL), accounting for about 97% of the total protein content of LDL-CHOL. The determination of ApoB can directly reflect the level of LDL-CHOL.
Fat egg A 1 is a good lipoprotein, which can prevent coronary heart disease and arteriosclerosis. The biggest feature is that the higher the ratio, the better. Therefore, it is a good phenomenon that the lipoprotein A 1 in your blood test report is greater than the normal range, indicating that there is no problem with your own fat metabolism.
Clinical significance of apolipoprotein B
The fasting serum APOB level of normal people is about 0.80 ~1.20g/L.1.996. Framingham, USA, used a calibrator that met the WHO -IFCC international reference material standard, and proposed that 1.20g/L was the critical value, which was roughly equivalent to the 75th percentile of men and the 80th percentile of women, and the number of patients greater than this value was higher than that of women. 0.05, female p
Increase: adults > l. 0g/ L slightly higher; >1.2g/l is obviously increased, which is common in type ⅱ hyperlipidemia cholestasis, coronary heart disease, nephropathy, cerebrovascular disease, hypothyroidism and psoriasis.