Early treatment of HIV infection is very important. Treatment can slow down the decline of immune function. HIV-infected people are at increasing risk of tuberculosis, bacterial pneumonia and pneumocystis carinii pneumonia, so early prevention is very important.
First, support therapy and increase the progressive consumption of AIDS patients as much as possible.
Second, immunomodulatory therapy:
(1) Interleukin -2(IL-2): It can improve the cytotoxicity of the body to HIV-infected cells limited by MHC, and also improve the activities of natural killer cells (NK) and lymphokine-activated killer cells (LAK) not limited by MHC.
(2) Granulocyte Colony Stimulating Factor (G-CSF) and Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF): Increase circulating neutrophils and improve the body's anti-infection ability.
(3) Lingmycin: activate the pituitary-adrenal cortex system, adjust the internal environment and function of the body, enhance the adaptability of the body to external environmental changes, stimulate the body to produce humoral antibodies, increase the total number of white blood cells, strengthen phagocytosis, activate the body's defense system, and resist the invasion of pathogenic microorganisms and viruses.
(4) Interferon (IFN):α- interferon (IFN):α- α can slightly increase CD4+T cells in some patients, and 40% of patients with Kaposi's sarcoma have tumor regression; ② Interferon -β (IFN-β): The effect of intravenous administration is similar to that of IFN-α, but the effect of subcutaneous injection on Kaposi's sarcoma is weak; ③ Interferon -γ (IFN-γ) can improve the activity of monocytes and macrophages and resist toxoplasmosis and other conditional infections.
Third, antiviral drugs:
(1) Drugs that inhibit the combination and penetration of HIV with host cells: Soluble rsCD4 can combine with HIV and occupy CD4 binding sites, so that HIVgp 120 cannot combine with CD4 on CD4 lymphocytes and cannot penetrate infected CD4 lymphocytes. Dosage: rsCD4 clinical trial 30mg/ day, intramuscular injection or intravenous injection for 28 days.
(2) Drugs that inhibit HIV reverse transcriptase (RT): By inhibiting RT, HIV replication is blocked.