In order to improve the prognosis of acute lymphoblastic leukemia, winter treatment is essential.
A commonly used drug for the treatment of acute lymphocytic diseases in children is called L-asparaginase, or another drug is called Peimendong.
The improvement of children's acute lymphocyte prognosis is due to the application of asparaginase, which plays a very important role in improving the prognosis of leukemia, so the treatment effect of children's leukemia is much better than that of adults!
At present, many hematology clinics have added asparaginase at the beginning of acute lymphocyte therapy in children. At present, it is found that asparaginase is very important for the treatment of acute leukemia, and the intensity of asparaginase use is closely related to the obvious improvement of the survival rate of children with acute leukemia. If the child's body can tolerate it, increasing the dose of asparaginase can prevent the recurrence of extramedullary leukemia (such as meningeal leukemia and testicular leukemia), which has a positive effect on treatment.
In recent years, the dosage of asparaginase has increased in the new treatment of low-risk, medium-risk and high-risk leukemia and portal hypertension.
In the treatment of acute lymphocytic diseases in children, we should understand the side effects of asparaginase.
①: Pancreatitis
Once pancreatitis occurs, the mortality rate is still quite high. Therefore, during the winter, the doctor will tell you to eat a low-fat diet in order to reduce the occurrence of pancreatitis. Because prevention of pancreatitis is more important than treatment. Pancreatitis caused by asparaginase often occurs during initial induction therapy. When asparaginase is used, a large number of tumor cells in the body are killed, and normal cells have not recovered, so the human body's resistance is very poor. Once severe pancreatitis occurs, many children die, so now we are very concerned about preventing pancreatitis caused by winter.
②: Hypoalbuminemia
The winter diet is also a matter of great concern to the families of children with acute diarrhea. The emphasis on low-fat diet does not mean absolute prohibition of oil. Some animal fat things are not recommended. Asparaginase can also cause hypoproteinemia. Where does our protein come from? In fact, these lean meats and boiled egg proteins contain high-quality protein, so low fat does not mean that there is no protein. On the contrary, in clinical treatment, it is necessary to provide a relatively adequate supply of protein for children with acute gonorrhea in the winter treatment stage.
③: Coagulation dysfunction.
On the other hand, asparaginase can cause blood coagulation disorder, so children's blood coagulation function should be monitored regularly before, during and after using asparaginase. Because once the disorder of coagulation occurs, it will also cause the child's life to be dangerous.
④: Blood sugar rises.
Another side effect of asparaginase is that it will lead to an increase in blood sugar. Therefore, when using asparagus, it is necessary to regularly monitor the fasting blood glucose concentration of children before, during and after use, so as to find asparagus-related diabetes or significantly increased blood glucose as soon as possible and deal with it in time.
⑤: Liver function damage
Asparaginase can also cause liver function damage. Therefore, while using asparaginase, doctors will also help monitor liver function regularly.
6. Allergic reaction
In addition, asparaginase has a primary side effect that needs our attention, that is, it will cause allergic reactions! This allergic reaction is sometimes immediate, that is, just like the use of penicillin, it can immediately cause life-threatening, and some will have a relatively delayed reaction. Therefore, skin test must be done before using asparaginase.
Then the problem is coming. How to do asparaginase allergy?
If you are allergic, it is recommended to use products from different batches and manufacturers. In the past clinical practice, children who were allergic after changing to different domestic manufacturers were all changed to imported asparaginase. Of course, some children are not allergic even if they use asparaginase produced in other countries. But some people are still allergic. What should I do? Desensitization treatment can be performed! However, the desensitization treatment of asparaginase must be carried out under the guidance of experienced specialists in blood hospitals.
Fortunately, in recent years, a new drug has appeared, which we call Peimendong for short. Generally speaking, the probability of allergic reaction of Peimendong is much lower than that of common L-asparaginase. Therefore, its application scope and security have been greatly improved and guaranteed. However, the disadvantage of Peimendong is that it is more expensive, because it is related to its manufacturing cost.