Traditional Chinese medicine has a long history, generally speaking, it is mild in nature and has little toxic and side effects. For a long time, it has been considered to be safe and effective, and accepted by most patients, but its side effects are often not paid enough attention. However, all drugs have their duality, which is the same, with therapeutic effects and disadvantages. That is, drugs can be treated and bring benefits to people; It will also cause harm to the human body and induce. Even western medicines produced according to modern standards have common adverse reactions. Therefore, drug regulatory authorities in various countries have formulated a series of policies and regulations to monitor and investigate adverse drug reactions. China established the National Adverse Drug Reaction Monitoring Center on 1989. /kloc-0 officially joined the who international cooperation organization for drug monitoring in March, 1998, and1October 1999 and 165438 issued the management measures for adverse drug reaction detection (for trial implementation). This marks the beginning of the implementation of the ADR reporting system in China.

In China, as early as the second century AD, drugs were classified into three categories according to their performance and efficacy in the book Shen Nong's Herbal Classic. With the development of clinical pharmacy in China, the monitoring of adverse drug reactions (ADR) has been attached great importance by health administrative departments and medical circles, and the reports of ADR and poisoning caused by traditional Chinese medicine have gradually increased. This shows that diseases induced by traditional Chinese medicine have also begun to attract attention. Among them, the occurrence of drug-induced diseases and adverse reactions is often related to the following:

1. Apply traditional Chinese medicine according to the theory of syndrome differentiation and treatment of traditional Chinese medicine, fight poison with poison, and achieve the purpose of treating diseases. If arsenolite is toxic, it can attack poison, relieve asthma and treat cancer; Datura flower is poisonous, which can anesthetize and relieve pain and treat all kinds of pain. However, these drugs should not be used in large doses, and the course of treatment should be moderate, and they should not be abused without authorization. If the misuse of toxic drugs causes toxic reactions, its poisoning manifestations include acute poisoning and chronic poisoning, which can cause organ and tissue damage and physiological and biochemical changes. The degree of poisoning is closely related to the toxicity, dosage and duration of medication. In severe cases, it will lead to death.

2. Drug-induced diseases related to compatibility of traditional Chinese medicines. Traditional Chinese medicine (TCM) clinical drugs based on syndrome differentiation and treatment are mostly compound drugs, which can be added or subtracted according to the patient's condition, so as to improve the curative effect and reduce the curative effect, but if the compatibility is improper, it can increase the toxic and side effects. For example, ephedra can strengthen the toxic and side effects of aconite drugs; Compatibility with Angelica sinensis or Glycyrrhiza uralensis can weaken the toxicity of Dioscorea bulbifera to the liver. Another example is the compatibility of dried ginger, licorice and aconite, which can reduce the toxicity of aconite and increase its cardiotonic effect. Shennong's Classic of Materia Medica points out in compatibility: "These seven emotions should be used in harmony and should be mutually beneficial. Don't use those evil and antagonistic ones. If they are poisonous, they can take advantage of those who are afraid of each other and kill each other. Don't share. " Explain the compatibility principle of traditional Chinese medicine. The incompatibility of traditional Chinese medicine is said to be eighteen opposites and nineteen fears. This is a summary of clinical medication experience of traditional Chinese medicine.

3. Irrational drug use. It is reported that oral ginseng often causes dizziness, headache, palpitation, insomnia, photophobia, sore throat, toothache and other drug-induced reactions.

4. Drug dependence. Drug dependence is a reaction after drug withdrawal. Some drugs will produce withdrawal symptoms once they are stopped. For example, in recent years, it has been reported that a patient took Niuhuang Jiedu tablets for a long time due to illness, and he showed withdrawal symptoms when he stopped taking them one year later. In addition, 2 1 case of dependence caused by long-term use of senna leaves was reported. The shortest time to take senna leaves is 6 months, and the longest time is 1 1 year. Withdrawal symptoms are similar to morphine dependence, but to a lesser extent, and its mechanism needs to be studied.

5. Mutagenesis and carcinogenesis. It has been reported that the volatile oils of asarum, Acorus gramineus and other plant medicines contain 0. 1% safrole, which can induce liver cancer one year later when mixed with feed for rats. It has also been reported that long-term overdose of Dioscorea bulbifera can cause liver damage; Chinese patent medicines such as Liushen Pill contain bezoar, which can cause gastrointestinal bleeding and erosion. Because bezoar is mainly composed of cholic acid, it can destroy the gastric mucosal barrier after contact with gastric mucosa.

It is reported that there are as many as 460 kinds of traditional Chinese medicines and proprietary Chinese medicines that cause drug-induced diseases. For example, in order to reduce the adverse reactions of traditional Chinese medicine, while monitoring the adverse reactions of traditional Chinese medicine, we should strictly and conscientiously do the following:

Seriously implement the GAP standard requirements of traditional Chinese medicine. The toxicity and non-toxicity of traditional Chinese medicine are often affected by many factors, such as cultivation, variety, application place, origin, collection, processing, processing, environmental pollution and so on. Therefore, we must strictly control the quality of all aspects of traditional Chinese medicine to prevent the purchase of counterfeit drugs, counterfeit drugs and moldy drugs. Therefore, licensed pharmacists and pharmaceutical technicians must have a high sense of responsibility and a high level of professional knowledge, so that all counterfeit drugs and moldy drugs are rejected, and unknown substitutes are not used, and pesticides harmful to human health are not used to store and protect drugs.

Strictly follow the processing norms of traditional Chinese medicine. The things sold in pharmacies should conform to the "processing standard". Ensure the quality of traditional Chinese medicine, prevent adverse reactions and ensure the safety and effectiveness of medication.

Improve the level of rational drug use. It is necessary to master and understand the efficacy and theoretical knowledge of traditional Chinese medicine, so as to treat and use drugs based on syndrome differentiation. Rational use of compatibility of traditional Chinese medicine compound. Avoid unnecessary incompatible drugs. Pay attention to dosage, usage and course of treatment. In particular, it is necessary to strictly control some toxic traditional Chinese medicines or proprietary Chinese medicines, and children and the elderly should pay more attention.

Pay attention to the decocting method of traditional Chinese medicine. For example, the container, temperature and time of decocting, the first decocting, the second decocting, the package decocting, the time of taking medicine, before and after meals and so on. Strengthen and improve the management of instructions for Chinese patent medicines. Instructions should be standardized, and the adverse reactions and precautions caused by drugs should be indicated, especially those caused by Chinese patent medicines containing toxic components, so as to facilitate users' understanding and attention.