In the early stages of hand, foot and mouth disease, the child will first have fever, cough and drooling and other symptoms like upper respiratory tract infection. Some children may have nausea, vomiting and other symptoms. Later, oval or pike-shaped blisters appear on the backs of the fingers and toes of the hands and feet, and there is a red halo around the blisters The fluid in the blisters is clear, and the long axis of the blisters is consistent with the skin pattern.

Then the center depression of the blister turns yellow, dry, and peel off (desquamation), in addition to scattered firmer light red papules or herpes on the ends of the fingers and toes.

At the same time in the mouth, such as lips, tongue oral mucosa, gums, there are also scattered blisters, but the blisters in the mouth quickly burst and formed gray-white dots or gray-white layer of membrane surrounded by a reddish halo, in the gray-white membrane can be seen under the punctate or flaky vesicles.