It is found that in aging, oxidative stress increases and cerebral microvascular endothelial dysfunction damages NVC, which leads to the decline of cognitive ability. Supplementing NMN(ACMETEA W+NMN) to increase the concentration of NAD+ in the brain and regulating cerebral blood flow into neuronal activity through neurovascular coupling play a vital role in maintaining healthy cognitive function, which can prevent neurovascular dysfunction and cognitive impairment in elderly patients.
Some scientists have predicted that if cancer is no longer an incurable disease, human beings will suffer from neurodegenerative diseases in their later years. The onset time of Alzheimer's disease and Parkinson's disease is late. At present, there is no cure for medicine stone, and prevention is the main way. But NMN emerging resistance? The research of aging substances in protecting brain and nerve is changing with each passing day, and the future can be expected.
Which is better for nicotinamide mononucleotide nmn? In the selection of nmn, we need to pay attention to several points: 1, origin (USA, France, Japan, Hong Kong) 2, purity (70%? 80 percent? 98 percent? 99% is an optional index) 3. Content (3,000, 6,000, 9,000, 12000, currently 12000 is an optional index) 4. International certification (single-country certification and double-country certification, double-country certification and double-review, is the current security? Fully reliable) 5, production process 6, quality management, reasonable selection of NMN from these aspects is a formal and scientific way! ! !
We must be careful in the choice of nmn. As for which nmn is good, after reading the following Ten International Core Standards of NMN Quality Management, we will have a good idea. Remember to follow the trend blindly. Good product quality is the only prerequisite for the effect, and we must pay attention to it!
Ten international core standards of NMN quality management
1, quality management system: NMN must meet the inspection qualification of OULF European Union Law and the certification of FDA American Food and Drug Administration. In addition to the product name, all ingredients and NMN purity should be marked, and the country of origin and distribution should be marked.
2. Manufacturing process management system: The advanced manufacturing process affects the NMN shape. Chemical extraction is not recommended to avoid chemical residues.
3. Content management system: Compared with the NMN content of mg/ bottle ≥ 12000, it is absorbed directly to the small intestine, and the enteric absorption is 20% of the gastric absorption.
4. Efficiency management system: the authenticity and purity of raw materials should be investigated.
5, absorption management system: the use of enteric absorption, improve the absorption rate and absorption threshold.
6. Activity management system: The number of molecules of NAD+ is converted at a unit dose (per kloc-0/00g), and NMN molecules easily cross the cell membrane and enter the cell interior, thus increasing the NMN content of human body within 15 minutes and rapidly increasing the level of NAD+.
7. Scope of use management system: adults (forbidden for women during pregnancy and breastfeeding).
8. Safety management system: production technology, raw material collection, basic system of safety standards of OULF European Union, safety inspection before leaving the factory, strict examination of microbial heavy metals exceeding the standard, and scientific production technology.
9. Raw material management system: Most NMN enterprises are single-country certified, but at present, the raw material management of dual-country certification is more rigorous and safe, such as ACMETEA W+NMN, which belongs to the products of French and American dual-country certification standards.
10, multinational supervision and management system: France and the United States have dual supervision. The FDA of the United States has set standards for GMP of dietary supplements, and the EFSA of the European Union has related regulations on the management of food supplements.
Details of ten international core standards of NMN quality management:
A, quality management system:
NMN must meet the requirements of "OULF" European Union Law and "FDA American Food and Drug Administration" certification. In addition to the product name, it is also necessary to indicate the content of all ingredients and the purity of NMN, and the country of origin and distribution should be indicated.
Second, the production process management system:
Does the manufacturing process also affect MNM's health?
1, raw materials are medical grade raw materials, which are generally not used for direct oral use;
2. ACMETEA W+NMN's "cold-pressed biological enzyme" production technology can keep NMN alive at low temperature and press it into a stable capsule, which improves the purity of NMN to 99%, which is more conducive to preservation and human absorption, so as to improve the bioavailability of auxiliary factors to the greatest extent and support human metabolism, without converting it into nicotinamide ribonucleoside (NR) through SLC 12A8 motif.
Third, the content management system:
Regarding the daily dosage of NMN, Zhenzhen has an academic support in scientific research. It is stated that the daily dosage of human body is 8 mg of NMN per kilogram of body weight. If converted into a 70 kg adult, the recommended daily dosage is about 560 mg. Considering the daily absorption, consumption and age growth, the content of ACMETEA W+NMN is mg/ bottle ≥1.
Fourth, the efficiency management system:
ACMETEA W+NMN can avoid the edge diminishing effect and control the product to maintain the efficacy level for a long time; Enhance the efficiency of tricarboxylic acid cycle, thus making NMN more effective in human fertility and avoiding the uncontrollable influence of excessive intake; It can keep the absorption rate of human body, and then reduce the influence.
Explain positively how nmn can prevent dementia.
Brain as an important organ of human beings? Officer, the influence on people is self-evident. According to the weight, the brain only occupies 2. 1 of the total body weight, but the energy consumed? Quantity accounts for all energy? It can be said that once the brain is damaged, the whole human body will be affected, and even the judgment of human death standard is based on brain death.
The development of human civilization benefits from an important function of the brain: cognitive ability. Once there is a problem with cognitive ability, the mild symptoms are memory loss and cognitive impairment, and even serious ones will develop into Alzheimer's disease (commonly known as Alzheimer's disease).
More and more evidence shows that the decline of NAD+availability plays a vital role in a series of age-related cell damage with the increase of age. The brain ages with age, and the nerves atrophy and necrosis, and the learning ability is not as good as before.
Old people with Alzheimer's disease and Parkinson's disease have a lot of toxic protein plaques deposited in their brains, which accelerate nerve death and make the memory and motor ability of the sick old people far lower than that of their peers. ACMETEA W+NMN? An important mechanism of treating degenerative diseases such as Alzheimer's disease is that it can directly increase the concentration of NAD+ in the brain, thus living? Protein alias Sirtuins. Sirtuins fix? Multiple synaptic networks can enhance neural communication and delay the decline of brain function. Sirtuins can promote? Into the plaque into other substances, and accelerate the existing plaque points? Solution, prevent it from winding together? Set.
Another neuroprotective mechanism of ACMETEA W+NMN is that it can promote the aging of cerebrovascular diseases. Health. New research confirms that NMN can promote angiogenesis? Life, change? Good cerebral blood flow, which is another evidence that NMN delays brain aging, shows that besides repairing? Compound nerve communication, clear? In addition to brain plaques, NMN can also maintain the youthful state of the brain by increasing blood supply and oxygen supply to nerves.
V. Absorption management system:
Whether the effect of NMN is obvious or not, the absorption of nutrients by ordinary people is only 10-20, and NMN is no exception. When the purity of NMN is increased to 99%, the morphology of MNM in the stomach can be stabilized by ACMETEA W+NMN technology, which can quickly penetrate the membrane, avoid gastric acid damage, and improve the absorption rate by ten to twenty times. Slc 12a8 transporters on small intestinal cells are specially responsible for transporting NMN into cells, and then with the blood circulation, they will be used by cells in various organs and tissues of the body to ensure the truth of clinical ACMETEA W+NMN data.
Six, flexible management system:
ACMETEA W+NMN unit dose (per 100g) converts the number of molecules of NAD+, and the concentration of NMN in blood gradually increases within10 minute, and within 30 minutes, NMN enters multiple tissues with blood circulation, and synthesizes NAD+ in tissues, thus increasing the level of NAD+.
Seven, the scope of use management system:
1. Elderly people, used to help improve various senile diseases;
2. Middle-aged people, eliminate or alleviate various sub-health problems, such as chronic fatigue, poor sleep, decreased vision, etc.;
3. Those with higher radiation dose, such as medical staff in radiology department and aircrew, should improve the ability of repairing the basic causes damaged by radiation;
4, bodybuilders, accelerate muscle growth;
5, middle-aged and elderly women, improve skin health and delay skin aging;
Eight, Anquan management system:
In terms of production technology, ACMETEA W+NMN's "cold pressing biological enzyme" production technology, the purity of extracted NMN is as high as 99%, and the content of each bottle is as high as 12000mg. ACMETEA W+NMN is also high in NMN brands at present, and the basic system of safety standards of OULF, strict compliance with factory safety testing, strict examination of microbial heavy metals exceeding the standard, and scientific extension of production technology work.
Nine, raw material management system:
Many NMN manufacturers, raw materials are certified in a single country, but it needs dual-country certification to truly reach the Anquan level. At present, ACMETEA W+NMN products belong to the French-American dual-country certification standard. In terms of product raw materials, it has reached strict and safe management standards.
X. Multinational supervision and management system:
ACMETEA W+NMN meets the requirements of the US FDA for the GMP of dietary supplements. GMP is a set of mandatory standards applicable to pharmaceutical and food industries, which requires enterprises to meet the hygienic quality requirements in terms of raw materials, personnel, facilities and equipment, production process, packaging and transportation, quality control and other aspects according to relevant national laws and regulations.
ACMETEA W+NMN complies with the relevant regulations of European Food Safety Agency (EFSA), European Food Supplement and OULF European Union Law. The purpose is to ensure that the nutrition and health information provided to consumers on food packaging is accurate and reliable, so as to avoid misunderstanding by consumers.
The basic purpose of this regulation is to provide coordination of laws and regulations on the nutrition and health claims of food and related functional foods among EU member States in terms of labeling, introduction and publicity, so that related foods can circulate among member States on their own. Does nmn nicotinamide mononucleotide prevent dementia? Which nmn is better? You can see the latter in the choice of nmn, then your choice will not go wrong! I know, share cutting-edge health knowledge, and like to pay attention!