1964, Rao identified a non-protein amino acid β-N- oxalyl -L-α, β-diaminopropionic acid, namely ODAP, which is the main component of Lathyrus sativus poisoning. It exists in the whole growth cycle of Lathyrus sativus, mainly in the most active growth parts.
Poisoning by Lathyrus sativus can be divided into nerve poisoning and bone poisoning. Among these four toxins, only BAPN can cause bone poisoning, and the rest are all poisoned by Lathyrus sativus.
Among these toxins, ODAP neurotoxin is the most studied at present, and the rest are not studied or rarely studied. Different varieties of Lathyrus sativus seeds contain different toxins, but toxicological studies show that ODAP is the direct cause of Lathyrus sativus poisoning.
Extended data
The neurotoxicity of Lathyrus sativus was initially manifested as depression and dyskinesia, and then paralysis of hind limbs occurred. After being absorbed into the blood, ODAP passes through the blood-brain barrier, showing protective inhibition at the initial stage of central nervous system injury, then changing from inhibition period to excitation period, and finally the central nervous system exceeds the inhibition limit, and dies due to paralysis of the central respiratory blood vessel motor center.
Reference materials? Baidu Encyclopedia-Songliu