guì zhī
2 English Referencecassia ig [Landau Chinese-English Dictionary]
ramulus [Landau Chinese-English Dictionary]
ramulus cinnamomi [湘雅医学专业词典]/>
cassiabarktree branchlet [湘雅医学专业词典]/>
Ramulus Cinnamomi (拉) [Nomenclature Review Committee of Chinese Medicine. Committee. Chinese Medicine Nomenclature (2004)]
cassia ig [Chinese Medicine Nomenclature Validation Committee. Nomenclature of Chinese medicine (2004)]
3 OverviewCinnamomum cassia ig is the name of the traditional Chinese medicine, out of the "Newly Revised Materia Medica". It is the dried shoots of Cinnamomum cassia Presl, family Camphoraceae[1].
The Pharmacopoeia of the People's Republic of China (2010 edition) records the pharmacopoeial standard of this Chinese medicine.
4 Latin nameRamulus Cinnamomi (La) (Nomenclature of Chinese Medicine (2004))
5 English namecassia ig (Nomenclature of Chinese Medicine (2004))
6 SourceCinnamon twig is the dried shoots of Cinnamomum cassia Presl, family Camphoraceae[1].
Cinnamon sticks are the shoots of Cinnamomum cassia Presl, family Camphoraceae[2].
7 OriginCinnamomum cassia is mainly produced in Guangdong, Guangxi and other places [2].
8 Sexual flavor and meridianGui Zhi is pungent, sweet and warm in nature; it enters the lung, heart and bladder meridians [2].
9 Efficacy and Indications of Gui ZhiGui Zhi has the efficacy of sweating and relieving muscles, warming the menstruation and Yang, leveling the flush and lowering the rebelliousness, and is used to treat wind-cold cold and flu, wind-dampness paralysis, dysmenorrhea, cold pain in the epigastric region, amenorrhea, phlegm cough and wheezing, chest paralysis and palpitation, running dolphin, edema, and dysuria [2].
10 Usage and dosage of Gui ZhiDecoction: 3-9g [2].
11 ContraindicationsGui Zhi is contraindicated in patients with various kinds of bleeding and pregnant women [2].
12 Chemical composition of Cinnamomum cassiaCinnamomum cassia contains volatile oil, mainly cinnamaldehyde [2].
13 Pharmacological Actions of Cinnamomum cinnamomiDecoction of Cinnamomum cinnamomi is antipathogenic to microorganisms[2].
Cinnamomum cinnamomi reduces intestinal tension, mildly promotes bile secretion, is anticoagulant and diuretic [2].
For the pharmacology of cinnamon aldehyde, see article on cinnamon [2].
Cinnamaldehyde prevents the formation of stress gastric ulcers in mice, and also has jaundice, antispasmodic, sedative, analgesic, anticonvulsant and antipyretic effects [3].
Cinnamaldehyde increases the secretion of catecholamine release and also anti-tumor and elevates white blood cells [3].
14 Pharmacopoeia standard of Cinnamomum cassia 14.1 NameCinnamomum cassia
Guizhi
CMNAMOMI MMULUS
14.2 SourceThis product is the dried shoots of Cinnamomum cassia Presl, family Camphoraceae. Harvested in spring and summer, remove the leaves, sun-dried, or sliced and dried.
14.3 PropertiesThe product is long cylindrical, multi-branched, 30-75cm long, the diameter of the thick end of 0.3-1cm. the surface is reddish brown to brown, there are longitudinal ribs, fine wrinkles and pimple-like leaf scars, branch scars and bud scars, lenticels punctiform. The texture is hard and brittle, easy to break. The slices are 2-4mm thick, the cut surface is reddish brown in the skin part, yellowish white to light yellowish brown in the wood part, and the pith part is slightly square. There is a special aroma, taste sweet, slightly pungent, skin flavor is stronger.
14.4 Identification(1) cross-section of the product: epidermal cells 1 column, shoots are sometimes seen unicellular non-glandular hairs. Cork cells 3 to 5 columns, the innermost column of cells thickened outer wall. The cortex has oil cells and stone cells scattered. Middle column sheath stone cell cluster intermittently arranged in a ring with fiber bundles. Phloem with secretory cells and fibers scattered. Formation layer conspicuous. Xylem rays 1 to 2 columns of cells wide, containing brown matter; ducts single scattered or 2 to several aggregates; wood fiber wall is thin, not easy to distinguish from wood thin-walled cells. Pith cell walls slightly thick, lignified. Fine calcium oxalate needle crystals are occasionally seen in ray cells.
Powder reddish brown. The stone cells are square or rounded, 30-64 μm in diameter, with thick walls, some of which are thin on one side. Phloem fibers mostly in bundles or single scattered, colorless or brown, pike-like, some margins toothed protruding, 12-40 μm in diameter, wall very thick, lignified, pore grooves are not obvious. The oil cells are orbicular or ellipsoid, 41 to 104 μm in diameter, and the wood fibers are numerous, often in bundles, with oblique pores or intersecting in a cross shape. Cork cells yellowish brown, surface view polygonal, containing reddish brown material. The main conduit is ciliated, about 76μm in diameter.
(2) Take 0.5g of powder, add 10ml of ethanol, tightly stoppered, immersed for 20 minutes, shaking, filtration, and take the filtrate as the test solution. Take cinnamaldehyde control product, add ethanol to make a solution containing 1μl per 1ml, as the control solution. According to thin-layer chromatography (Appendix VIB), absorb 10-15μl of the test solution, 2μl of the control solution, were spotted on the same silica gel G thin-layer plate, with petroleum ether (60-90 ℃) ethyl acetate (17:3) as an unfolding agent, unfolding, take out, air drying, and sprayed with dinitrophenylhydrazine ethanol test solution. In the chromatogram of the test article, in the corresponding position with the chromatogram of the control article, showed the same orange-red spots.
(3) take 2g of powder, add 10ml of ether, soak for 30 minutes, shaking, filtered, filtrate evaporated, residue add trichloromethane 1m1 to dissolve, as a test solution. Take 2g of Cinnamomum cassia control herb, and make control herb solution by the same method. According to the thin layer chromatography (Appendix VIB) test, absorb the above two solutions of 15ul, respectively, point in the same silica gel G thin layer plate, so that the strip, with petroleum ether (60 ~ 90 ℃) ethyl acetate (17: 3) as an unfolding agent, unfolding, remove, drying, sprayed with vanillin sulfuric acid reagent, heated at 105 ℃ until the spot color is clear. In the chromatogram of the test article, in the corresponding position with the chromatogram of the control herb, the same color spots.
14.5 Check 14.5.1 MoistureNot more than 12.0% (Appendix IX?). H second method).
14.5.2 Total ashnot more than 3.0% (Appendix IX? K).
14.6 LeachateDetermined in accordance with the alcohol soluble leachate method (Appendix X? A) under the hot leaching method, using ethanol as a solvent, not less than 6.0%.
14.7 Content determinationDetermined by high performance liquid chromatography (Appendix VI B).
14.7.1 Chromatographic conditions and system suitability testOctadecylsilane-bonded silica gel as filler; acetonitrile and water (32:68) as the mobile phase; detection wavelength of 290 nm; the theoretical plate number should not be less than 3,000 based on the peak of cinnamaldehyde.
14.7.2 Preparation of the control solutionTake the appropriate amount of cinnamaldehyde control, weighing, methanol made of 10μg per 1ml. Each 1ml contains 10μg of solution, that is obtained.
14.7.3 Preparation of the test solutionTake the powder (sieve No. 4) about 0.5g, precision weighing, placed in a stoppered conical flask, precision add 25ml of methanol, weighing, ultrasonic treatment (power 250W, frequency 40kHz) for 30 minutes, cooled, and then weighing, methanol to make up for the loss of weight, shaking, filtration, precision measurement of the filtrate 1m1, placed in a 25m1 measuring flask, add methanol to make a solution containing 10μg per 1ml, that is, the preparation. 25m1 measuring flask, add methanol to the scale, shake well, that is obtained.
14.7.4 Determination methodPrecisely aspirate 10μl of each of the control solution and test solution separately, inject into the liquid chromatograph, determination, that is, obtained.
This product is calculated according to the dry product, containing cinnamaldehyde (C9H8O) shall not be less than 1.0%.
14.8 Cinnamon sticks tablets 14.8.1 ConcoctionRemove impurities, wash, moisten, cut thick slices, dry.
The product is in the form of thick slices of orbicular or oval shape. The surface is reddish brown to brown, sometimes with punctate lenticels or longitudinal ridges. The cut surface of the skin part of the reddish brown, yellowish white or light yellowish brown wood part, pith part of the class of round or slightly square, has a special aroma, taste sweet, slightly pungent.
14.8.2 Identification(except cross-section)? Same as the herb.
14.8.3 Inspection, leachate, content determinationSame as the herb.
14.8.4 Flavor and attributionPungent, sweet, warm. Attributed to the heart, lung and bladder meridians.
14.8.5 Functions and IndicationsSweating and relieving the muscles, warming the meridians, assisting Yang to transform qi, and calming the flushing and lowering qi. It is used in treating wind-cold flu, cold pain in the epigastrium and abdomen, menstrual closure with blood cold, paralytic pain in joints, phlegm, edema, palpitation, and running dolphin.
14.8.6 Method of Use and Dosage3~10g.
14.8.7 CautionUse with caution in pregnancy.
14.8.8 StorageIn a cool and dry place.
14.9 ExistenceChinese People's Pharmacopoeia of 2010
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