Symptoms and signs are nonspecific, determined by the organs and systems involved, often covered by the primary disease, and fatal before amyloidosis is suspected. The kidney system is the most severe, with only mild proteinuria in the early stage, which can develop into systemic edema, hypoproteinemia and massive proteinuria.

Hepatic amyloidosis has hepatomegaly but less jaundice, and severe hepatomegaly (liver weight >100%; 7 kilograms). Although the excretion of sodium sulfobromophthalein is increased (rarely sustained) and alkaline phosphatase is increased, the liver function is often normal, and portal hypertension occasionally occurs, resulting in esophageal varices and ascites. Skin lesions cause waxy or translucent changes. Purpura caused by amyloidosis of small vessels. Heart involvement is very common, including enlargement of heart, refractory heart failure and common arrhythmia. Atrial arrest was found in several related families. Amyloidosis of gastrointestinal tract can cause abnormal esophageal movement, stomach weakness, abnormal peristalsis of large intestine and small intestine, malabsorption, bleeding or pseudoobstruction. Tongue hypertrophy is common in primary or myeloma-related amyloidosis. Hard, symmetrical, no tenderness, such as Hashimoto's disease or Riddle's thyroid disease.

Due to thyroid amyloidosis, in rare cases of multiple myeloma, amyloidosis arthropathy is similar to rheumatoid arthropathy, and the clinical manifestations of peripheral neuropathy are less, which are more common in familial amyloidosis and primary or myeloma-related amyloidosis. Amyloidosis involving the lung (mainly AL amyloidosis) is characterized by localized pulmonary nodules, tracheobronchial injury or extensive alveolar deposition.