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Lowering Blood Lipid Effects
Chenpi has better lowering blood lipid effects. By establishing a rat model of hyperlipidemia induced by high-fat diet, it was confirmed that the aqueous
extract of Guang Chen Pi could significantly reduce the body mass, serum total cholesterol (
TC), and low-density lipoprotein cholesterol (LDL-C) levels, and elevate the level of high-density lipoprotein cholesterol (HDL-C) in hyperlipidemic rats by affecting the metabolism of triglyceride (TG), thus improving the hyperlipidemia. Similarly, the alcoholic extract of tangerine peel also had a significant reduction in TG levels in the hyperlipidemic rat model, significantly reducing serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP
) activity and serum free fatty acid content, and at the same time, it could make the triglyceride metabolism-related enzymes, adipose triglyceride lipase (ATGL
), lipoprotein lipase, lipoprotein lipase, lipoprotein lipase and lipoprotein lipase, to increase LDL-C levels, thus improving the hyperlipidemia. p>), lipoprotein lipase (LPL) and hepatic lipase (HL), and hormone-sensitive triglyceride lipase (HSL) were elevated, and hormone-sensitive triglyceride lipase (HSL) was decreased. In addition, the flavonoid content of Chenpi was positively correlated with its anti-lipase activity, and polymethoxyflavonoids had a significant lipid-lowering effect on Chenpi
, among which, Chuan Chenpi Piin had the most significant effect and was a potential lipase inhibitor.
Cough suppressing, asthma and expectorant effect
Chenpi extract has a good effect of cough suppressing, asthma and phlegm. It has been proved that the total alkaloids of Chenpi and the monomer alkaloid Xinfulin can significantly down-regulate the expression of eosinophils and their serum immunoglobulin E (IgE), interleukin IL-4 and IL-5 levels in the bronchoalveolar lavage fluid (BALF) of guinea-pigs with histamine-induced experimental asthma, and have significant anti-asthmatic activity; the volatile oil of Chenpi can also have the effects of asthma and cough, and reduce the cough and phlegm in the bronchoalveolar lavage fluid (BALF) of the allergic guinea-pigs. The volatile oil of Chenpi also has asthma-relieving and cough-relieving effects, and can reduce the number of eosinophils in the bronchoalveolar lavage fluid of sensitized guinea-pigs, and significantly prolong the latent period of coughing and reduce the number of coughs in mice stimulated by ammonia.
Inhibition of pulmonary fibrosis
Chenpi has the effect of inhibiting pulmonary fibrosis, can alleviate inflammation and collagen deposition in lung tissue, and has an ameliorative effect on pulmonary fibrosis in mice; Chenpi alkaloids and their hydrochloride inhibit the proliferation of lung fibroblasts in mice, and the best inhibitory effect of the compounds are p-hydroxyphenylethanamine salts, which can inhibit proliferation of lung fibroblasts in mice through the up-regulation of cyclooxygenase-2 (COX2), Prostaglandin E2 (PGE2), prostaglandin E2 receptor 2 (EP2) levels, and inhibit the expression of transforming growth factor-β1 (TGF-β1) signaling, thereby alleviating the process of pulmonary fibrosis.
Regulating qi and strengthening the spleen
Chenpi has the effect of regulating qi and strengthening the spleen, and can effectively relieve spleen deficiency and its related symptoms. It has a significant alleviating effect on the spleen deficiency and its related symptoms, such as poor digestion and absorption, disorders of gastrointestinal hormones, immune cytokines and oxidative stress induced by reserpine in rats; meanwhile, it can have a certain regulating effect on the intestinal flora of the spleen-deficient rats, and it can up-regulate certain short-chain fatty acid chain-producing bacteria and anti-inflammatory bacteria and down-regulate certain bacteria related to the aggravation of the spleen-deficiency, so as to make the intestinal flora of the spleen-deficient rats rebalance, thus alleviating the spleen-deficiency and related symptoms. It can rebalance the intestinal flora of rats with spleen deficiency, thus alleviating the spleen deficiency and related symptoms.
Other
In addition to the above pharmacological effects, Chenpi also has some anti-inflammatory activity.