However, it should be noted that this product can obviously inhibit leukocyte migration, inhibit platelet adhesion and aggregation reaction, and prolong bleeding time. When combined with oral anticoagulants, naproxen can be preferentially combined with protein, which increases the free form of anticoagulants in blood and is prone to poisoning and bleeding. The side effects are lighter than those of aspirin, indomethacin and phenylbutazone, but there are still gastrointestinal reactions and even bleeding, and animals with digestive tract ulcers are prohibited. Can cause jaundice and angioneurotic edema; Long-term use should pay attention to renal function damage; When combined with furosemide or hydrochlorothiazide diuretic, it can reduce the diuretic effect of sodium excretion.