What is the efficacy and indication of Schizonepeta tenuifolia? Please, 3Q.
China Pharmacopoeia: Pinyin name of Schizonepeta tenuifolia J Ρ n π Jiè English name HERBA SCHIZONEPETAE alias Toona sinensis, Toona sinensis, Artemisia quadrangularis, and PseudoSoviet origin This product is the dry aerial part of Schizonepeta tenuifolia Briq. of Labiatae. In summer and autumn, bloom is harvested when the top and ears are green, impurities are removed and dried. Processing Schizonepeta tenuifolia: removing impurities, spraying clean water, washing, moistening thoroughly, cutting into sections and drying in the sun. Schizonepeta spike: Pick the flower spike. Charcoal of Schizonepeta tenuifolia: Take the Schizonepeta tenuifolia segment and fry it according to the charring method (Appendix II D) until the surface is dark brown. Mustard spike charcoal: clean Schizonepeta tenuifolia spike, stir-fry according to the charcoal-frying method (Appendix II D) until the surface is dark brown. Pungent in nature, slightly warm. Meridian, lung and liver meridians. Indications: relieving exterior syndrome, dispelling wind and penetrating rash. Used for colds, headaches, measles, rubella and ulcers. Stir-frying charcoal to treat hematochezia, metrorrhagia and postpartum blood dizzy. Usage and dosage: 4.5 ~ 9g. Store in a cool and dry place. Excerpt from China Pharmacopoeia Dictionary: The Pinyin name of Schizonepeta tenuifolia originated from Wupu Materia Medica is J Ρ n ɡ Jiè, alias Pseudosu, Mousou (Benjing), Jiangsu (Wupu Materia Medica), Tooth-stabilizing Vegetable (Yunan Materia Medica), and Artemisia quadrangularis (Annals of Traditional Chinese Medicine) originated from labiatae. In autumn, when the ear of bloom is green, the aboveground parts are cut and dried. Also, it is called "Schizonepeta tenuifolia" and "Schizonepeta tenuifolia" by picking the flower ear separately, then cutting the stems and branches and drying them in the sun. Habitat distribution is distributed in most parts of the country. Most parts of the country have production, mainly in Jiangsu, Jiangxi, Hubei and Hebei. Dry whole grass with square stems, longitudinal grooves on all sides, multiple branches on the upper part, 45 ~ 90 cm long and 3 ~ 5 mm in diameter; The surface is purplish red and pubescent. It is light and brittle, easy to break, fibrous in cross section, yellow-white, with white loose pulp in the center. The leaves are opposite, the leaves are divided, the lobes are slender, yellow, shriveled and curled, and broken incompletely; Brittle and easy to fall off. The branches are supported by spikes of cymbals, which are green cylindrical and 7 ~10 cm long; Most of the corollas have fallen off, leaving only a green calyx tube with four small brown-black nuts inside. The breath is fragrant, and the taste is slightly astringent and pungent. It is better to have light purple, thin stems and many dense spikes. The chemical composition contains volatile oil1.8%, and the main components in the oil are d-menthone, racemic buprenone and a small amount of d-limonene. Pharmacological action: Rabbits with artificial fever, taking orally 2 g (crude drug)/kg of Schizonepeta decoction and infusion, have little antipyretic effect. In vitro, high concentration (1: 100) has anti-tuberculosis effect. Processing Schizonepeta tenuifolia: clean impurities, slightly soak in water, take out and cut into sections, dry and fry Schizonepeta tenuifolia: put the cut Schizonepeta tenuifolia in a pot, stir-fry with slow fire, take it out and let it cool (the method of frying Schizonepeta tenuifolia is the same). Charred Schizonepeta tenuifolia: Take the cut Schizonepeta tenuifolia and put it in a pot, stir-fry it with strong fire until it is dark and persistent, spray less water, take it out and dry it in the sun (the method of charring Schizonepeta tenuifolia is the same). Pungent and warm in nature. ① Classic: "pungent and warm." ② The Origin of Medicine: "The temperature tastes bitter." Meridian entering the lung and liver meridians. ① Compendium: "Entering the Foot to Silent Yin Meridian and Divide Qi." ② "Explanation of the nature of drugs processed by Lei Gong": "Entering the lung and liver meridians." (3) Herbal Words: "Meridian of Foot Jueyin, Shaoyang and Yangming." Functions: Indicating publication, expelling wind and regulating blood; Stir-fry charcoal to stop bleeding. Treat common cold, fever, headache, sore throat, vomiting blood, bleeding in the stool; Metrorrhagia, postpartum blood halo; Carbuncle swelling, scabies, scrofula. Schizonepeta tenuifolia has the same effect, but the divergent force is stronger. (1) The Classic: "Treating cold and heat, rat fistula, scrofula with sores, broken knots with qi accumulation, blood stasis, dampness and arthralgia." (2) The Theory of Medicinal Properties: "Treating evil wind and thief wind, crooked mouth and face, stubborn body, guilty conscience and forgetfulness will make things worse. Main evil gas, in addition to labor, cure swelling; Take a grip, cut it with five liters of water, boil it with two liters, and divide it into two servings in cold, so as to promote blood circulation, transmit the deficiency of qi in the five internal organs, sweat and remove cold wind; "They pounded it with vinegar to seal up the swelling." ③ Meng Wei: "Postpartum stroke makes me stiff, so I should grind the wine and take it." ④ Herbal Diet: "Help the spleen and stomach." ⑤ Edible Materia Medica: "Back pain, sweating, beriberi of husband, vexed bones and muscles, yin and yang toxicity, typhoid headache, dizzy head, and anxious hands and feet." ⑥ "Rihuazi Materia Medica": "Benefiting the five internal organs, promoting digestion and relieving qi, and sobering up. Cook hot food and fry tea to cure head wind and sweat; Fried with black bean sauce to cure typhoid fever. " ⑦ "Materia Medica": "Treat head wind, fatigue, sores and scabies, and women's bloody wind." ⑧ Herbal Medicine in Southern Yunnan: "Treat traumatic injuries and apply toxic sores. Treat hematemesis. " "Spike of Schizonepeta tenuifolia can clear the wind, stop headache, improve eyesight, relieve heat and pain in lung, liver and throat, reduce swelling, remove toxic substances and disperse sores and carbuncle. "Cure hematochezia, stop the sudden collapse of women, eliminate wind and heat, dredge lung, qi and nasal obstruction." Pet-name ruby "compendium": "dispel wind and heat, clear the head, benefit the throat and eliminate sores and swelling. "Strong treatment, dark eyes, sores, depressed yin, vomiting blood, epistaxis, bleeding, bloody dysentery, collapse, hemorrhoids and leakage." Administration and dosage for oral administration: decoction,1.5 ~ 3 RMB; Or into the pill, scattered. External use: ramming, grinding, blending or decocting and washing. Pay attention to spontaneous sweating due to exterior deficiency and headache due to yin deficiency. ① Theory of Medicinal Properties: "Schizonepeta tenuifolia has been suffering from thirst for a long time." ② Notes on Wei Hang Ji: "Anyone who takes Schizonepeta herb should not eat fish." ③ Compendium: "Anti-donkey meat and fish without scales." (4) Herbal Classic of Mercaptor: "Those who suffer from superficial deficiency and sweat should avoid it; Do not use it for those with blood deficiency, cold and heat due to rheumatism and cold; "Those who have a headache due to fire due to yin deficiency should be careful not to go astray." Store in a cool and dry place. Attachment ① Treatment of wind-heat headache: Schizonepeta spike and gypsum are equally divided. For the end. It costs two yuan each time, and the tea is adjusted. ("Yong lei zhong Fang") 2 cure the head diseases, blood fatigue, headache, dizziness: Schizonepeta is the last. San Qian for every drink. ("Ophthalmology Longmu Lun") ③ Treatment of wind-heat lung obstruction, sore throat, inability to speak, or choking if something: Schizonepeta spica, Platycodon grandiflorum, Glycyrrhiza uralensis (roasted). The top is rough and the bottom is rough. Four yuan per serving, one lamp of water, three slices of ginger, fried for six points, removed the residue, and served warm after eating. ("Bureau Prescription" Schizonepeta Decoction) ④ Cure all wind, mouth and eye deviation: 1 kg of Schizonepeta tenuifolia and 1 kg of mint. Grind in a sand basin, wring raw silk juice in a porcelain, and fry it into paste; I have three points left, one point left, and two points left for my daily work, with cream and pills as big as buttonwood. Take twenty pills each time, and you can take three pills as early as dusk. Avoid moving things. ("Experience Rear") ⑤ Treatment of bleeding in stool: (1) Schizonepeta tenuifolia, fried, is the end. Drink two yuan per meter, and the woman drinks with wine. You can also mix noodles for wonton. ("Experience") (2) Schizonepeta and Sophora japonica. Stir-fried purple is the end. Every time you take San Qian, green tea will be served. ("Simple and Simple Prescription") ⑥ Treat postpartum blood dizzy, build heart, eyes fall, wind shrinks to the dead: dry Schizonepeta, pound and sieve. Every time you use the last two dollars, the boy urinates a wine lamp, adjusts the heat, picks his teeth when he shuts his mouth, and pours it into his nose when he closes it. ("Materia Medica") ⑦ Treatment of urine and hematuria: Schizonepeta tenuifolia, shrinking sand, equal parts. For the end. Glutinous rice drinks three times a day in San Qian. ("The Simple Prescription of Lakeside Collection") 8 Treatment of Hemorrhoids, Leakage, Swelling and Pain: Schizonepeta cooked soup and washed it every day. ("Simple and Simple Prescription") 9 Treat constipation, acute pain in the lower abdomen and swelling pain in the anus, without asking for a new long time: rhubarb (urine obstruction halved) and Schizonepeta tenuifolia (stool obstruction halved), equally divided. Respectively at the end. One or two yuan for each service, adjusted with warm water, and temporarily added or subtracted. (Yi Ming Lun Fang Huan San) ⑩ Treat all scabies: Schizonepeta, honeysuckle and Smilax glabra, equally divided. For the end, Rehmannia glutinosa is a pill, and Wuzi is big. Take 100 pills every Dan and night, with tea and wine. ("Materia Medica") ⑾ Treatment of wind toxicity, widowhood, redness, swelling and hardness: one liter of mouse glue (slightly fried), four ears of Schizonepeta. Tame rough and loose. Every time you take San Qian, take a cup of water, fry it until five minutes, remove it from me, put it in bamboo juice and mix it evenly, and take it three times a day. ("Shenghui Fang") ⑿ Cure the wet feet: pound the leaves of Schizonepeta tenuifolia. (Simple Prescription) Clinical application for the treatment of skin pruritus: take one or two clean Schizonepeta tenuifolia spikes, grind them into fine flour, put them into gauze bags after sieving, spread them evenly on the affected area (if the range is wide, it can be divided into pieces), and then rub them repeatedly with the palm of your hand until the palm and the affected area feel hot. Treatment of acute and chronic urticaria and all skin pruritus, mild1~ 2 times, severe 2 ~ 4 times will be effective. Note: Schizonepeta tenuifolia belongs to the same plant, and it is also used as Schizonepeta tenuifolia in northeast and other places. The morphology of Schizonepeta tenuifolia is similar to that of the previous species, except that the final lobe of the leaf is wide and oval or ovate-lanceolate. Spikes are large and sparse; Bracts ovoid, purplish purple; Corolla blue purple, longer than sepals 1/2. Excerpt from Dictionary of Chinese Materia Medica: The origin of Schizonepeta tenuifolia comes from Wupu Materia Medica. Its phonetic name is J and N ɡ Jiè, and its English name is Fine Leaf Schizonepeta Herb. Herb of Fine Leaf Schizonepeta is also known as False Sue, Rattan and Ginger Mustard. The ecological environment is: 1. Born on the hillside roadside or in the valley. The altitude is between 540-2700m m. More cultivation, but also wild. 2. Born at an altitude of1300-2,000 m on the edge of pine forest, grass on hillside or wet grassland. Distribution of resources: 1. It is distributed in Heilongjiang, Liaoning, Shanxi, Shaanxi, Gansu, Qinghai, Henan, Henan, Sichuan, Guizhou, Jiangsu, Zhejiang, Fujian and Yunnan. 2. Distributed in Northeast China, Inner Mongolia, Hebei, Shanxi, Shaanxi, Gansu and other places. Pharmacological effect 1. Antipyretic and analgesic effect: The mixed vaccine of typhoid fever was used to make rabbits fever, and Schizonepeta tenuifolia decoction or ethanol infusion of 2g/kg was given to the stomach, which had only a weak antipyretic effect. Schizonepeta decoction has antipyretic and analgesic effects. D- menthone in Schizonepeta tenuifolia is the main component of analgesia, and 3- methylcyclohexanone also has analgesic effect. 2. Antimicrobial effect: Schizonepeta decoction has strong antibacterial effect on Staphylococcus aureus and Diphtheria in vitro. Secondly, it has certain inhibitory effects on Bacillus anthracis, Streptococcus B, Salmonella typhi, Shigella dysenteriae, Pseudomonas aeruginosa and human tuberculosis. 50% Schizonepeta tenuifolia decoction 0. 1ml per chicken embryo has no inhibitory effect on influenza A virus PR8 strain. 3. Hemostasis: The bleeding time of mice was measured by Akohob's method, and the clotting time of rabbits was measured by capillary method, and the hemostasis time of raw Schizonepeta tenuifolia and Schizonepeta tenuifolia charcoal was compared. All the drugs were prepared with normal saline, 2g/kg in rabbits and 5g/kg in mice, with normal saline as control. The results showed that raw Schizonepeta tenuifolia could not significantly shorten the bleeding time, while Schizonepeta tenuifolia charcoal shortened the bleeding time by 72.6%. The raw Schizonepeta tenuifolia shortened the clotting time by 30%, while the charred Schizonepeta tenuifolia shortened by 77.7%, which indicated that the charred Schizonepeta tenuifolia had hemostatic effect. 4. Other effects: Schizonepeta tenuifolia has a weak inhibitory effect on cancer cells in vitro. Schizonepeta decoction can obviously inhibit auricle swelling in mice, and also has obvious anti-inflammatory effect on inflammation caused by acetic acid. It is also reported that the main anti-inflammatory component of Schizonepeta tenuifolia is 1- humulone. Benzofurans, 3- octanol and B- pinene also have anti-inflammatory effects. The IC50 of the former for 3a- hydroxysteroid dehydrogenase is 8. 1μg/ml. The lethal dose of mice injected with Schizonepeta tenuifolia decoction was 30046 76.5 mg/kg. Pungent in nature; Slightly bitter; Slight dampness due to menstruation and lung; Liver meridian function is mainly used to dispel wind; Solve the table; Penetrating rash; Stop bleeding. Main cold and fever; Headache; Itchy eyes; Cough; Sore throat; Measles; Carbuncle swelling; Scabies; Hemorrhage; Hematemesis; Bloody stool; Collapse and leakage; Administration and dosage of postpartum blood halo: decoction, 3-10g; Or pill, powder. External use: appropriate amount, decocted in water for fumigation and washing; Tamping; Or grind and disperse. Pay attention to spontaneous sweating due to exterior deficiency and headache due to yin deficiency. 1. Theory of Medicinal Properties: Schizonepeta tenuifolia has been suffering from thirst for a long time. 2. "Wei Hang Ji Tan": Anyone who takes Schizonepeta wind medicine should not eat fish. 3. The Compendium is against donkey meat and fish without scales. 4. "Herbal Classics": patients with superficial deficiency and sweating should avoid it; Do not use it for those with blood deficiency, cold and heat due to rheumatism and cold; Those who have a headache due to the red face caused by fire due to yin deficiency should be careful to go astray. Various discussions 1. Classic: Treating cold and heat, plague, scrofula, sore, stagnation, qi accumulation, blood stasis and dampness arthralgia. 2. "The Theory of Medicinal Properties": Treat evil wind and thief wind, mouth and face? Evil, obstinacy all over, guilty conscience and forgetfulness, benefit strength and add essence. Main evil gas, in addition to labor, cure swelling; Take a grip, cut it with five liters of water, boil it with two liters, and divide it into two servings in cold, so as to promote blood circulation, transmit the deficiency of qi in the five internal organs, sweat and remove cold wind; Tamp the powder and vinegar to seal the swelling. 3. Meng Wei: Postpartum stroke is stiff, and the wine is taken at the end. 4. "Dietotherapy Materia Medica": Help the spleen and stomach. 5. Edible Materia Medica: the main blood and fatigue are full, with back pain, sweating, beriberi of husband, vexation of bones and muscles, yin and yang toxicity, typhoid headache, dizzy head, and anxious hands and feet. 6. "Rihuazi Materia Medica": benefit the five internal organs, digestion and qi, and sober up. Cook raw cooked food and fry tea to cure head wind and sweat; Fried with black bean juice for typhoid fever. 7. "Materia Medica": Treating head wind, fatigue, sores and scabies, and women's bloody wind. 8. "southern Yunnan materia medica": treating injuries from falls and applying toxic sores. Treat hematemesis. Spike of Schizonepeta tenuifolia can clear the wind, stop headache, improve eyesight, relieve heat and pain in lung, liver and throat, reduce swelling, remove toxic substances and disperse sores and carbuncle. Treat hematochezia, stop women's sudden collapse, eliminate wind and heat, dredge lung, qi and nasal orifices. 9. "Compendium": Dispel wind and heat, clear the head, benefit the throat and eliminate sores and swelling. Strong treatment, dark eyes, sores, yin TUI, vomiting blood, epistaxis, bleeding, bloody dysentery, collapse, hemorrhoids and leakage. Excerpt from Chinese materia medica