Theophylline drugs are a kind of classic drugs widely used at present. Recent studies show that theophylline can treat asthma mainly by inhibiting the activity of phosphodiesterase, reducing the decomposition of cyclic adenosine monophosphate and cyclic guanosine monophosphate, antagonizing adenosine receptors and reducing the concentration of intracellular calcium ions. It can inhibit mast cells from releasing inflammatory mediators and antagonize inflammatory mediators, and directly stimulate the release of endogenous catecholamine. Therefore, theophylline not only has spasmolytic and anti-inflammatory effects, but also has immunomodulatory and respiratory muscle regulating effects.

6 anticholinergic drugs can inhibit the M receptor of airway smooth muscle, prevent the contraction of airway smooth muscle caused by cholinergic nerve excitation, and also inhibit the excessive secretion of mucus caused by cholinergic nerve excitation after holidays, which is more suitable for asthma (or asthmatic bronchitis) complicated with chronic bronchitis.

7 Specific immunotherapy In specific immunotherapy, in the early years, due to the nonstandard purity of allergen extract, injection dosage and desensitization course, the curative effects of each unit were quite different, and there were occasional serious allergic reactions. Therefore, some countries, such as Britain and some regions, once banned the use of SIT to treat asthma. In recent years, with the standardization of allergen purification and the improvement of treatment methods, the safety and efficacy of SIT have been greatly improved. 65438-0998 The United Nations World Health Organization officially affirmed the desensitization effect of standardized allergens on allergic diseases (including asthma). It is pointed out that SIT is the only etiological treatment that can affect the natural course of allergic diseases and prevent allergic rhinitis from developing into asthma. At the same time, the standardization and treatment scheme of allergen purification was also formulated.

8 Conventional immunotherapy Conventional immunotherapy is a commonly used classic SIT, which is divided into two stages: initial treatment and maintenance treatment, through subcutaneous injection.