Trunature grape seed is better, because it not only contains anthocyanins, but also contains resveratrol extract. It has a better anti-aging effect.

Resveratrol, a natural plant antitoxin, is a plant non-flavonoid polyphenolic substance induced by plants under stress (ultraviolet irradiation, insect pests, etc.). It is widely found in plants such as tiger nuts, grapes, lily family, peanuts, etc. It was first obtained from the roots of hairy leaf rutabaga in 1940. Under natural conditions, it exists in the form of cis/trans-resveratrol, cis/trans-resveratrol glycosides and some oligomers, with trans-resveratrol being the most stable and biologically active. It has also been pointed out that some oligomeric forms of resveratrol have stronger activity than resveratrol monomer. Resveratrol has strong polarity, insoluble in water, but soluble in strong polar organic solvents.

Physiological activity of resveratrol for topical use on the skin As a potent antioxidant widely used in skin care products, and there is currently no restriction on the concentration of its use at home and abroad, it can be seen that resveratrol has a high degree of safety. About the role of resveratrol on the skin is currently focused on the following aspects:

1, SIRT1 agonist and estrogen-like effect SIRT1 as an important substance affecting the life cycle of the living organism has been widely studied. And as one of the first SIRT1 agonists discovered, resveratrol is given too much expectation. In vitro experiments have shown that resveratrol can mimic the caloric restriction anti-aging response, prompting the acetylation of SIRT1 to specific substrates, participating in the regulation of the cell cycle, and resisting skin aging through the p53 and JNK pathways. At the same time, low-dose resveratrol shows a weak estrogen-like effect, which can counteract skin aging caused by the decline from estrogen.

2, antioxidant resveratrol has a strong antioxidant capacity, especially good at scavenging hydroxyl radicals, the most active site in its single hydroxyl ring on the hydroxyl group. And it can enhance the content of glutathione and anti-superoxide radicals, protect the mitochondria of fibroblasts, and reduce the incidence of mtDNA deletion mutation rate. Hung et al. found that the antioxidant power of resveratrol is significantly better than that of VC and VE.

3, Inhibition of tyrosinaseSome scholars have pointed out that the whitening power of resveratrol is better than that of arbutin and VC ether. Experiments have shown that resveratrol, as a non-peptide endothelin antagonist, can inhibit tyrosinase activity and related protein expression. A controlled clinical trial involving Estee Lauder found that 40 women all experienced improvements in facial hyperpigmentation after a 4-week period of use.

4, anti-microbial Resveratrol shows excellent microbial activity, G / G-bacteria, some fungi and even mites have an inhibitory effect.

5, Anti-inflammatory Resveratrol reduces the level of skin inflammation through multiple mechanisms, such as interfering with the PKD/NF-κB pathway, inhibiting AP-1 binding, regulating NO content, and enhancing macrophage activity.

6, Inhibiting hyperkeratosis of epithelial cellsResveratrol can bind to aromatic hydrocarbon receptors, enter the cell nucleus, and further bind to the corresponding receptors to exert powerful biological effects. Some scholars found that resveratrol can down-regulate the expression of AQP3 through the SIRT1/ARNT/ERK pathway, and then inhibit the value-added of keratinocytes.

7, protect AQP3As we all know, AQP3 is an important water channel protein in the skin, which can transport molecules such as water, glycerol, urea, etc., and is involved in maintaining the normal water content of the skin. Experiments have found that resveratrol can reduce the decline in AQP3 content in the skin after UV irradiation and slow down skin aging.

8, inhibit photodamage in vitro experiments 0.01mmol / L of resveratrol can reduce fibroblasts by UVA irradiation induced by the release of inflammatory mediators IL-1 / IL-6, thereby reducing the production of MMP, correcting the collagen disintegration; at the same time, resveratrol can be effective in inhibiting the UVB irradiation by the production of reactive oxygen species as well as NO, to prevent cell membrane lipid peroxidation, reduce cellular damage, improve the skin's health and improve the quality of life. At the same time, resveratrol can effectively inhibit the production of reactive oxygen species and NO after UVB irradiation, prevent lipid peroxidation of cell membrane, reduce cellular damage and improve erythema after sun exposure.