0.5mg of tetrodotoxin can poison a person to death. The toxic component of puffer fish is tetrodotoxin, which is a neurotoxin, and a person can die from ingesting tetrodotoxin 0. 5mg-3mg. The most toxic parts of puffer fish are gonads, ovaries, liver, followed by kidneys, blood, eyes, gills and skin, puffer fish meat contains less toxin. The toxin is heat-resistant, 100 ℃ for 8 hours are not destroyed, 120 ℃ for 1 hour to destroy, salt pickling, sunlight also can not destroy the toxin. Tetrodotoxin is one of the most toxic non-protein poisons found in nature, with a toxicity equivalent to 1,250 times that of sodium cyanide, and the toxicity of a single tetrodotoxin roe is enough to kill dozens of people. The toxin usually causes nerve paralysis, vomiting, and then cardiac and respiratory arrest.