Chuanxiong is generally considered to be relatively safe and has no obvious side effects. Very few women may have early menstruation and increased menstrual flow. However, it should be reminded that no matter what medicine it is, it should follow the principle of moderation, and never take it in large quantities without authorization, otherwise it will have an impact on the body.

Toxic and side effects of Ligusticum chuanxiong

This product and its effective components have little toxicity. The lethal dose of Ligusticum Chuanxiong water-soluble crude preparation to mice by intraperitoneal injection and intramuscular injection were 65.86g/kg and 66.42g/kg, respectively. The lethal dose of Ligustrazine to mice by intravenous injection was 239mg/kg. The subacute toxicity test was given continuously for 4 weeks (5 ~10 mg/kg per day), and no toxic symptoms and obvious pathological changes were found in experimental dogs. Ligusticum chuanxiong Hort. extract 1.5g/kg or 3g/kg was given to rats for 2 1 day. After administration of 1 week, there were blood-like attachments around the hair and nostrils, and salivation occurred. In the high dose group, the activity of acetylglucosaminidase in urine decreased, the hematocrit of Hb and red blood cells in blood decreased significantly and the average platelet volume increased significantly.

Clinical application of this product has not found obvious side effects, and it is generally considered to be safe. Very few women may have early menstruation and increased menstrual flow.

Ligusticum chuanxiong hort

Effects on central nervous system

Chuanxiong has obvious sedative effect. The volatile oil of Ligusticum chuanxiong hort has inhibitory effect on the activity of animal brain, but has exciting effect on the respiratory center, vascular motor center and spinal cord reflex center of medulla oblongata. 25-50g/kg Ligusticum Chuanxiong decoction can inhibit the spontaneous activity of rats, and has more obvious sedation on mice than rats. It can also prolong the sleep time of pentobarbital, but it can't antagonize the excitement of caffeine, and it can't prevent the convulsion or fatal effect of pentamethene tetrazole and cocaine.

The volatile oil of Ligusticum chuanxiong produced in Japan has inhibitory effect on the activity of animal brain, but it has excitatory effect on the vascular motor center, respiratory center and spinal cord reflex of medulla oblongata. With the increase of dose, all of them become inhibitory.

Effects on the heart

It is found that Ligusticum Chuanxiong can enhance blood circulation, increase heart rate, strengthen myocardial contractility and dilate blood vessels in animals, and these effects increase with the dose. Moreover, Chuanxiong has a very obvious effect on acute myocardial ischemia and hypoxia caused by Pit.

Effect on smooth muscle

The 10% aqueous solution of Ligusticum chuanxiong Hort. extract can stimulate the pregnant uterus in vitro, make its tension increase and contraction increase, and finally form contracture. A large amount will paralyze the uterus and stop the contraction.