Contents 1 Pinyin 2 Overview 3 Alias ??of Beiliujinu 4 Source and origin 5 Nature and taste 6 Function and indication 7 Precautions for use 8 Chemical composition 9 Pharmacological effects of Beiliujinu 10 Pharmacopoeia standards of Beiliujinu 10.1 Product name 10.2 Source 10.3 Properties 10.4 Identification 10.5 Inspection 10.5.1 Moisture content 10.5.2 Total ash content 10.6 Extract 10.7 Content determination 10.7.1 Chromatographic conditions and system suitability test 10.7.2 Preparation of reference solution 10.7.3 Test solution Preparation 10.7.4 Determination method 10.8 Beiliu Jinu pieces 10.8.1 Processing 10.8.2 Nature, flavor and meridians 10.8.3 Function and indication 10.8.4 Usage and dosage 10.8.5 Storage 10.9 Source 11 References attached: 1 Use Prescriptions for the Chinese medicine Beiliu Jinu 2 Chinese patent medicines using the Chinese medicine Bei Liujinu 1 Pinyin

běi liú jì nú 2 Overview

Bei Liujinu is the name of a Chinese medicine, from "Commonly Used Herbal Medicines Among Folks in Zhejiang" is the alias of Lingyinchen recorded in "Chronicles of Traditional Chinese Medicine" [1]. The "Pharmacopoeia of the People's Republic of China" (2010 edition) records the pharmacopoeia standards of this traditional Chinese medicine. 3 Alias ??of Northern Liujinu

Golden Bell Artemisia, Yellow Flower Artemisia, Northern Liujinu, Garden Herb [2]. 4 Source and production area

Scrophulariaceae plant Siphonostegia chinensis Benth. of the whole plant[2]. Mainly produced in Jiangsu, Anhui, Zhejiang, Yunnan, Guangxi and other places [2]. 5 Nature and flavor

Bitter, cold [2].

6 Functions and Indications

Clear away heat and dampness, activate blood circulation and remove blood stasis[2].

1. Treat jaundice hepatitis, cholecystitis, favismosis, urinary tract stones, dysuria, edema and abdominal distension, bloody dysentery, bloody stranguria, postpartum stasis and abdominal pain, and bruises and pain [2]. Decoction: 9~15g[2].

2. Treat traumatic bleeding, burns and scalds[2]. Grind into powder and sprinkle or mix for application [2]. 7 Precautions for use

Pregnant women should not take it[2]. 8 Chemical composition

This product contains apigenin, luteolin, etc., as well as cardiac glycosides and volatile oils [2]. Volatile oil contains α-limonene, 1,8-cineole, menthone, etc. [2]. The above-ground part contains cinnamon, isochadium, ryegrass lactone, etc. [2]. 9 Pharmacological effects

This product can dilate bile ducts, promote bile excretion and liver cell regeneration; it has a protective effect on experimental liver injury [2]. It has inhibitory effects on typhoid dysentery and E. coli [2]. 10 Beiliujinu Pharmacopoeia Standard 10.1 Product name

Beiliujinu

Beiliujinu

SIPHONOSTEGIAE HERBA 10.2 Source

This product is Xuan The dried whole plant of Siphonostegia chinensis Benth. Harvest in autumn, remove impurities and dry in the sun. 10.3 Characteristics

This product is 30-80cm long and covered with short hair. The roots are short, curved and slightly branched. The stems are cylindrical, ribbed, and sometimes have branches on the upper part. The surface is tan or dark brown; they are brittle and easy to break. The cross section is yellowish white, hollow or with white pith. The leaves are opposite, mostly fallen off and broken, the intact ones are pinnately deeply lobed, black and green. The racemes are terminal, the flowers have short stalks, the calyx is long and cylindrical, yellow-brown to black-brown, with 10 obvious longitudinal edges, the apex is 5-lobed, the corolla is brown and often falls off. The capsule is narrowly ovoid-elliptic, slightly shorter than the calyx, brown-black. The seeds are small. The smell is slight and the taste is light.

10.4 Identification

(1) Cross section of the stem of this product: non-glandular hairs can be seen on the epidermis, with 2 to 4 cells of non-glandular hairs. The cortex is composed of 2 to 4 columns of cells. The pericycle fibers are ring-shaped. Phloem is narrow. The cambium layer is not obvious. Wood has more than 10 rows, composed of vessels and wood fibers, with single rows of ray cells. The parenchyma cells of the marrow are closely arranged, and some cells have fine pits.

(2) Take 2g of this product powder, add 20ml of methanol, ultrasonicate for 30 minutes, filter, and concentrate the filtrate to 1ml as the test solution. Take another luteolin reference substance and add methanol to make a solution containing 1mg per 1ml as the reference solution. According to the thin layer chromatography (Appendix VIB) test, draw 5 ul of each of the above two solutions, place them on the same silica gel G thin layer plate, use toluene-ethyl formate formic acid (5:4:1) as the developing agent, and develop. Take it out, dry it, spray it with 1% aluminum trichloride test solution, heat it at 105℃ for a few minutes, and inspect it under a UV lamp (365nm). In the chromatogram of the test product, fluorescent spots of the same color appear at the positions corresponding to the chromatogram of the reference substance. 10.5 Inspection 10.5.1 Moisture content

shall not exceed 12.0% (Appendix IXH Method 1). 10.5.2 Total ash content

shall not exceed 8.0% (Appendix IXK). 10.6 Leachables

Determine according to the hot soak method under the alcohol-soluble leachables determination method (Appendix X A), using 70% ethanol as the solvent, not less than 10.0%. 10.7 Content determination

Determine according to high performance liquid chromatography (Appendix VID). 10.7.1 Chromatographic conditions and system suitability test

Use octadecylsilane compound silica gel as the filler; use acetonitrile 0.3% phosphoric acid solution (30:70) as the mobile phase; the detection wavelength is 349nm. The number of theoretical plates should not be less than 8,000 based on the luteolin peak. 10.7.2 Preparation of reference substance solution

Take an appropriate amount of luteolin reference substance, weigh it accurately, and add methanol to make a solution containing 25 μg per 1 ml. 10.7.3 Preparation of test solution

Take about 1g of this product powder (passed through No. 2 sieve), weigh it accurately, place it in a stoppered conical flask, add 25ml of methanol accurately, seal the stopper, and weigh Determine the weight, conduct ultrasonic treatment (power 250W, frequency 40kHz) for 30 minutes, let cool, weigh again, make up for the lost weight with methanol, shake well, filter, and take the filtrate to obtain. 10.7.4 Determination method

Precisely draw 10 μl each of the reference solution and the test solution, inject them into the liquid chromatograph, and measure.

This product contains no less than 0.050% luteolin (C15H1006) calculated as dry product. 10.8 Beiliu Jinu pieces 10.8.1 Processing

Remove impurities, wash, cut into sections and dry. 10.8.2 Nature, flavor and meridians

Bitter, cold. Returns to the spleen, stomach, liver, and gallbladder meridians. 10.8.3 Functions and indications

Promotes blood circulation and removes blood stasis, stimulates menstruation and relieves pain, cools blood, stops bleeding, clears away heat and removes dampness. Used for bruises, traumatic bleeding, blood stasis, amenorrhea, irregular menstruation, postpartum pain, scar accumulation, bloody dysentery, bloody stranguria, damp-heat jaundice, edema, abdominal distension, and excessive leucorrhea. 10.8.4 Usage and dosage

6～9g. 10.8.5 Storage

Store in a dry place. 10.9 Source