From the functional point of view, it can be divided into antihypertensive peptides, antioxidant peptides, cholesterol-lowering peptides, opioid peptides, high F-value oligopeptides, strong food peptides and so on.
Active peptides are closely related to nutrition, hormones, enzyme inhibition, immune regulation, antibacterial, antiviral and antioxidant activities. Polypeptides are generally divided into: polypeptide drugs and polypeptide health products. Traditional polypeptide drugs are mainly polypeptide hormones. 20 1 1 The development of polypeptide drugs has developed into various fields of disease prevention and treatment, especially the following fields.
1, anti-tumor polypeptide
The occurrence of tumor is the result of many factors, but it ultimately involves the regulation of oncogene expression. 20 13 found many tumor-related genes and regulatory factors. Screening peptides that specifically bind to these genes and regulatory factors has become a new hotspot in the search for anticancer drugs.
For example, somatostatin has been used to treat endocrine tumors in the digestive system; American scholars have found a hexapeptide that can significantly inhibit adenocarcinoma in vivo; Swiss scientists have discovered an octapeptide that can induce apoptosis of tumor cells.
2. Antiviral peptides
Viruses adsorb cells by binding to specific receptors on host cells, and rely on their own specific proteases for protein processing and nucleic acid replication. Therefore, peptides that bind to host cell receptors or peptides that can bind to active sites such as viral proteases can be screened from peptide libraries for antiviral therapy.
20 13 Canada, Italy and other countries have screened many small peptides with antiviral properties from peptide libraries, and some small peptides have entered the clinical trial stage.
In June, 2004, the Institute of Microbiology of China Academy of Sciences reported that the project "Study on the Cell Fusion Mechanism and Fusion Inhibitors of SARS Coronavirus" undertaken by the Institute of Microbiology of China Academy of Sciences had made great progress in cooperation with the Modern Virology Research Center of the School of Life Sciences of Wuhan University.
Experiments show that the designed HR2 polypeptide can effectively inhibit the infection of SARS virus to cultured cells, and the effective inhibitory concentration is at several nanomolar levels. Important progress has also been made in virus infection inhibition experiment and in vitro binding experiment of HR 1 with HR2.
Polypeptide drugs developed to prevent SARS virus fusion can prevent virus infection, and for patients infected with the virus, it can prevent the virus from spreading further in the body. The polypeptide medicine has dual functions of prevention and treatment. Researchers from the Cell Engineering Research Center of the Fourth Military Medical University have synthesized nine kinds of peptides that can effectively prevent and inhibit SARS virus from invading cells.
3. Cytokine mimic peptide
Since 20 1 1, it has become a hot research topic at home and abroad to screen cytokine mimetic peptides from peptide libraries by using known cytokine receptors.
Many growth factor mimetic peptides have been screened abroad, such as human erythropoietin, human thrombopoietin, human growth hormone, human nerve growth factor, interleukin-1 and so on. The amino acid sequences of these mimetic peptides are different from their corresponding cytokines, but they have the activity of cytokines and have the advantage of low molecular weight. 20 13 these cytokine mimetic peptides are in preclinical or clinical research stage.
4. Antimicrobial peptides
When insects are stimulated by the external environment, they will produce a large number of cationic peptides with antibacterial activity, and 20 13 screened out more than 100 antibacterial peptides. In vitro and in vivo experiments have proved that many antimicrobial peptides not only have strong antibacterial and bactericidal abilities, but also can kill tumor cells.
5. Polypeptide vaccine
Polypeptide vaccine and nucleic acid vaccine are one of the more important research aspects in the field of 20 13 vaccine research. 20 13 A great deal of research and development has been done on virus polypeptide vaccine in the world.
For example, 1999, NIH announced the clinical trial results of two HIV-I virus polypeptide vaccines in human body; Foreign scholars screened a polypeptide from the outer membrane protein E2 of hepatitis C virus (HCV), which can stimulate the body to produce protective antibodies. The United States is developing malaria multivalent antigen polypeptide vaccine; Cervical cancer human papillomavirus polypeptide vaccine has entered the second phase of clinical trials. China has also done a lot of work in the research of various polypeptide vaccines.
6. Diagnostic polypeptide
The main use of peptides in diagnostic reagents is as antigens to detect antibodies of corresponding pathogenic organisms. Polypeptide antigen is more specific than natural microorganism or parasite protein antigen, and it is easy to prepare.
20 13 antibody detection reagents assembled with polypeptide antigens include: detection reagents for hepatitis A, B, C, G virus, HIV, human cytomegalovirus, herpes simplex virus, rubella virus, Treponema pallidum, cysticercosis, trypanosoma, Lyme disease and rheumatoid disease. Most of the polypeptide antigens used were obtained by analysis and screening in the natural protein of the corresponding pathogen, and some of them were brand-new peptides screened in the peptide library.
2. As of 20 18, 1 1.5, the peptide has not been identified as pyramid scheme. Sea cucumber peptide is a product of Baidesheng Biomedical Technology Co., Ltd.
On July 6, 20 18, Laoting County Bureau of Commerce actively organized Laoting County Fang Ying Trading Co., Ltd., Tangshan Lv Xin Agricultural Development Co., Ltd., a leading agricultural industrialization enterprise, and Baidefu Biotechnology Co., Ltd., a biomedical high-tech enterprise, to go to Uzbekistan to participate in the "20 18 China Brand Commodities (Tashkent) Exhibition".
Overseas participation is the main marketing channel for enterprises to develop foreign trade. In order to help enterprises enter the international market, the County Bureau of Commerce contacted Tianjin International Exhibition Co., Ltd. to be responsible for the preparation of the exhibition and provide enterprises with various conveniences and assistance including text translation. In addition, this exhibition is included in the 20 18 national key overseas exhibition plan, and will enjoy the policy and financial support of special funds for foreign trade and economic development.
During the exhibition, Laoting specialty attracted the attention and purchase of visitors from Central Asia, Europe, Russia and other countries, and discussed cooperation intentions with many professional merchants. By participating in the exhibition, the enterprise not only introduced the products, but also deeply understood the product prices of foreign markets and peers, discovered the potential commercial demand, got a more comprehensive understanding of the industry status, and learned the experience of exhibitors from various countries, which greatly broadened their horizons.
The sea cucumber peptide products of Bedford Biomedical Technology Co., Ltd. attracted local doctors and agreed to come to China to discuss cooperation.
Extended data:
Enterprise information query method:
First open Baidu search "National Enterprise Credit Information Publicity System".
2. Enter "Baidesheng Biotechnology Co., Ltd." in the search box of the national enterprise credit information publicity system, and click Search.
Third, click on the search results and Badefort Biotechnology Co., Ltd.
Four, through the search, we can know that the enterprise is in a normal state of existence, not included in the abnormal business directory, nor does it belong to pyramid schemes.
Baidu encyclopedia-peptide
China Net-Laoting County Bureau of Commerce promotes enterprises to participate in exhibitions abroad.