Product name Cnidium monnieri extract

Botanical source Cnidium monnieri (L.) Cuss

Botanical origin Sichuan, Zhejiang

Extracted parts of fruits

Active ingredient Osthole

CAS No. 484-12-8

Size 10%98%

Molecular formula C15H16O3

Molecular formula C15H16O3

Molecular formula C15H16O3

Molecule number >Specification 10%-98%

Assay Method HPLC

Molecular Formula C15H16O3

Molecular Weight 244.29

Assay Method HPLC

About Osthole

Osthole is the dried fruit of Osthole Cnidium monnieri (L.) Cuss of Umbelliferae family. The dried fruit of Cnidium monnieri (L.) Cuss, family Umbelliferae. Mainly contains pinene, isovaleric acid lobster brain ester (bornyl isovalarate), parsley phenol methyl ether (osthol), dihydro parsley alcohol, bergamot lactone (berapten), serpentine (cnidiadin), isopimpinellin (isopimpinellin) and so on. 1.Anti-trichomonas effect:

Snake bed seed Chinese medicine external treatment of trichomonas vaginitis, but the effect of a single flavor of snake bed seed is not good or very weak, the role of its components have not been reported. In contrast, compound snake bed seed suppositories or lotions are very effective.

2. Sex hormone-like effect:

Snake bedstraw ethanol extract, daily subcutaneous injection in mice for 32 days, can prolong the estrous period, shorten the estrous intervals, and can make de-estrous rats to appear estrous, the ovaries and the uterus weight increase, there is a similar sex hormone-like effect, to the prostate gland, the seminal vesicles, the tibial muscle to increase the weight of the method (mice) to prove that the snake bedstraw extract has androgen-like effect. It has an androgen-like effect. It has no corrosive effect on the vaginal mucosa of rabbits.

3.Asthma-relieving effect:

3.1. The total coumarin of Cnidium sativum has asthma-relieving effect, which can make asthma patients' lungs raspy sound obviously reduced or disappeared, and can significantly increase the value of peak expiratory flow rate and improve the ventilation function of the lungs. Its action is manifested in the expansion of bronchial smooth muscle and improve pulmonary ventilation function. It is speculated that the total coumarin of Serpentine may have the effect of B-receptor stimulant, and its asthma-alleviating effect may be through the activation of the regulatory subunit of adenylate cyclase (B-receptor) on the smooth muscle and cell membranes, so that the intracellular cAMP is increased, which results in the phosphorylation of proteins in the intracellular storage site, the uptake of Ca2+, so that the Ca2+ into a bound state, and thus a decrease in intracellular free Ca2+, a decrease in the excitability of the smooth muscle contractile protein system, and muscle relaxation is achieved.

3.2. The total coumarin of C. serrata also has a certain expectorant effect.

3.3. Total coumarin of Cnidium serpentinum on guinea pigs due to inhalation of spasmolytic agents caused by experimental asthma has a significant protective effect in vitro can relax histamine spasmodic tracheal smooth muscle, can strengthen the guinea pigs lung perfusion flow, which shows that the drug has strong bronchodilator effect. In recent years, more research on serpentine, found more and more pharmacological effects.

4.1. Antifungal effects: serpentine, bergamot lactone and isohumulin in vitro test of tinea pedis has strong activity against tinea pedis bearded fungus; pepper toxin phenol has a significant antimycobacterial effect.

4.2.Antiarrhythmic: The aqueous extract of Cnidium serrulatum has preventive effects on chloroform-induced ventricular fibrillation in mice, on calcium chloride-induced ventricular fibrillation in rats and on ornithine-induced arrhythmia in rats, and has a significant therapeutic effect on the latter.

4.3. Local anesthesia effect of the aqueous extract of Cnidium serrata has blocking anesthesia on the isolated sciatic nerve of toads; infiltration anesthesia on guinea pigs and can be enhanced by epinephrine hydrochloride; vertebral anesthesia on rabbits, but no surface anesthesia on the cornea of rabbits. It also significantly prolonged the sleepogenic time of sodium pentobarbital.

4.4.Anti-metamorphic reaction serpentine can strongly inhibit the passive skin allergic reaction in mice, the overall guinea pig histamine wheeze has a protective effect on the slow response to the substance-induced contraction of the guinea pig isolated ileum as well as the guinea pig isolated ileum of the Schultz-Dzle reaction was obvious antagonism and blocking effect, and can inhibit the rat abdominal mast cell degranulation. The above effects were dose-dependent.

4.5. Anti-mutagenic snakebeds aqueous extract, through Ames, sister chromatid exchange of isolated cells and living mouse bone marrow cells chromosomal aberrations and multi-stained erythrocyte micronucleus test, showed that the drug has a strong anti-mutagenic effect.