1. Physiological growth

During the development of physiological skeleton, the activity of alkaline phosphatase in children is 1 ~ 2 times higher than that in normal people. Growing teenagers, pregnant women and eating foods with high fat content can all rise.

2. Pathological elevation

(1) Bone diseases such as rickets, rickets, bone malignant tumor, bone metastasis of malignant tumor, etc.

(2) Hepatobiliary diseases such as extrahepatic biliary obstruction, liver cancer, liver cirrhosis, and capillary bile duct hepatitis.

(3) Other diseases such as hyperparathyroidism.

3. Pathological decrease

It is found in severe chronic nephritis, thyroid insufficiency in children, anemia and so on.

The alkaline phosphatase in normal human serum mainly comes from bone, which is produced by osteoblasts, reaches the liver through blood circulation, and then is excreted through the biliary system. If the serum alkaline phosphatase is significantly increased, it often indicates that biliary tract excretion is blocked, and the patient may have cholestatic hepatitis or extrahepatic biliary obstruction.

Extended data:

Alkaline phosphatase (ALP or AKP) is an enzyme widely distributed in human liver, bone, intestine, kidney and placenta, which is secreted from liver to gallbladder. This enzyme can catalyze the removal of 5' phosphate groups from nucleic acid molecules, thus transforming the 5'-P end of DNA or RNA fragments into the 5'-OH end.

But it is not a single enzyme, but a group of isoenzymes. At present, there are six isozymes: AKP 1, AKP2, AKP3, AKP4, AKP5 and AKP6. Among them, 1, 2 and 6 are all from liver, the third from bone cells, the fourth from placenta and cancer cells, and the fifth from small intestinal villous epithelium and fibroblasts.

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