Irreversible chronic renal injury cannot be cured: once chronic injury is obtained and cannot be cured, renal function will gradually deteriorate. The toxic side effect of Alisma orientalis on kidney is mainly tubulointerstitial injury. Alisma orientalis is a drug for promoting diuresis and eliminating dampness. Sweet, light and cold in nature, entering kidney and bladder meridian. It has the effects of promoting diuresis, removing dampness, clearing away heat, resolving turbidity, and reducing blood lipid, and can be used for treating dysuria, bloating, diarrhea, heat stranguria, hyperlipidemia, etc. Taking medicine under the guidance of a doctor will generally not affect the kidneys, but if it is taken in large quantities for a long time, it will lead to renal tubulointerstitial damage, thus inducing kidney diseases, such as hematuria, oliguria, frequent urination, low back pain and other symptoms. Pay close attention to your own situation during taking medicine, at the same time, develop good living habits, ensure adequate rest and sleep, exercise properly, and maintain a happy mood. If there is any abnormality after taking the medicine, it is recommended to go to the hospital for examination as soon as possible and carry out appropriate treatment under the guidance of a doctor, so as to avoid any abnormality and affect your health.