Urticaria is a stubborn skin disease. Every year in autumn, it is a high incidence period, and the disease recurs repeatedly, and the skin has a severe itching feeling, especially at night, which affects normal sleep.
The causes of urticaria mainly include the following aspects.
1, food. Such as fish, shrimp, eggs and milk, followed by meat and plant food. Pigments, flavoring agents, preservatives, natural or synthetic substances in food can also cause urticaria.
2. Drugs.
3. Infection.
4. Inhalation. Pollen, dust, animal dander, smoke, feathers, fungal spores, volatile chemicals, etc.
5. Physical factors. Such as cold, heat, sunlight, friction and pressure.
6. Animal and plant factors. Such as insect bites, poisonous burrs and contact with nettles and wool.
7. Mental factors. The release of acetylcholine is caused by mental stress or excitement and exercise.
8. Genetic factors.
9. Visceral and systemic diseases.
Immune mechanism of urticaria: urticaria is a typical IgE-mediated type, which is caused by degranulation of mast cells mediated by IgE and release of inflammatory mediators such as histamine. The increase of capillary permeability produces wind masses. Erythema caused by vasodilation and itching caused by inflammatory mediators stimulating receptors. The classic theory is that antigen binds to specific IgE on the surface receptor of skin mast cells to stimulate mast cells to release histamine and other inflammatory mediators. At present, the most studied pathogenesis of chronic urticaria is the theory of IgE-mediated autoimmune diseases, and there is enough evidence to prove that most patients with urticaria have functional anti-IgE receptor antibodies and anti-IgE antibodies that can degranulate skin mast cells or basophils. Serum total IgE is higher than normal, or eosinophils or neutrophils are higher. Through the examination of skin tissue extract, it is found that histamine levels in rash and non-rash areas are increased, and histamine releasing factor can activate mast cells and basophils to release histamine.
It is scientifically proved that the immunoglobulin of IgE in the immune system of patients with urticaria is 1- 10 times higher than normal. These high IgE will disturb the immune system of human body, make it produce sensitive constitution, and thus lead to urticaria, thus strengthening the immune defense function of urticaria and improving the adaptability to the environment.
How should urticaria be treated?
1, avoid allergens
Patients with urticaria will get sick as long as they touch allergens, and paying more attention in the day can avoid allergens. When the symptoms are obvious, look at the surrounding environment and objects. If every occurrence is related to a fixed substance and environment, it may be an allergen.
2. recuperate allergic constitution and reduce IgE.
At present, doctors who have urticaria will instruct them to take antihistamines, and hormone drugs will be used appropriately if the condition is serious. However, drugs can only delay the onset of diseases, but can not fundamentally regulate allergic constitution. Chinese Internal Medicine (chapter on immune system diseases): Urticaria is mostly caused by allergic mechanism. Allergens in food (mostly xenogenic protein) stimulate human body, and make human body produce specific antibody IgE (immunoglobulin E), which is attached to mast cells or basophils in the body. When eating this food again, IgE antibody will combine with allergens in food, thus making mast cells and basophils release histamine. Histamine also acts on blood vessels, making them dilate and increase permeability, so a large amount of protein and liquid seep into the skin tissue, resulting in urticaria.
From the immunology of urticaria, the fundamental treatment should be to control IgE and adjust the balance of immunoglobulin. The treatment of intestinal probiotics focuses on adjusting internal constitution, improving allergic symptoms, effectively inhibiting the abnormality of IgE immunoglobulin, reducing IgE production induced by allergens, and finally playing a role in preventing and treating urticaria. How to reduce IGE value and balance immunoglobulin, the World Health Organization (WHO) pointed out in its guiding opinions on the treatment of allergic diseases that supplementing Xinminkang anti-allergic probiotics is a healthy treatment that can radically cure allergic constitution. Xinminkang antiallergic probiotics include six patented strains: Lactobacillus Roy, lactobacillus paracasei, Lactobacillus rhamnosus, Lactobacillus acidophilus, Lactobacillus salivarius and Streptococcus thermophilus. The patented strains in scientific proportion can activate cells to produce a series of physiological reactions by contacting with a special kind of cells in the intestinal tract, and finally realize the reduction of antibody immunoglobulin IgE in human blood, fundamentally regulate allergic constitution, enhance immunity and thoroughly treat allergic diseases. After taking xinminkang, it is fixed on intestinal mucosa, which can promote the secretion of interferon (IFN-Y), regulate TH 1 type immune response and inhibit immunoglobulin IgE, and improve the allergic phenomenon of TH2 immune response. Reduce the production of specific IgE antibody in serum; Adjust allergic constitution, inhibit allergic reaction and prevent allergic recurrence; Adjust the immune system, balance and enhance the immunity of the body.
3. Don't use antipruritic drugs casually.
There are many patients with urticaria who are prone to itching due to excessive sweating in summer, and when itching occurs, they use antipruritic drugs casually, and some drugs are only temporary, and they will appear again after the efficacy of itching, and it will be more serious. Therefore, you can't use drugs casually. If there is itching or a little abnormality, you should consult a doctor in time and let the doctor help you with the treatment to prevent urticaria from recurring.
4. Daily prevention
The causes of urticaria are also directly related to our living habits. For example, in diet, eating fish, shrimp and seafood frequently or some foods with more artificial colors will directly lead to urticaria. In daily diet, we should pay attention to hygiene and don't often use those processed foods. Don't often go to the sea bath or take a cold bath, but pay attention to your own warmth. Don't smoke or drink regularly, including the drugs we use will directly induce urticaria.