Since the outbreak of the COVID-19 epidemic, the Institute of Military Medicine of the Academy of Military Sciences has deployed emergency scientific research to tackle key problems, and at the same time promoted vaccine research and development in COVID-19 through multiple technical routes. COVID-19 mRNA vaccine made in China is another high-tech vaccine successfully developed and approved for clinical trial after recombinant COVID-19 vaccine (adenovirus vector) in our hospital. Studies have shown that this COVID-19 mRNA vaccine can not only induce high-level neutralizing antibodies in mice and cynomolgus monkeys, but also induce protective T cell immune response. The virus attack experiment of cynomolgus monkey virus showed that animals immunized with this vaccine could tolerate COVID-19 attack with high titer, effectively prevent virus replication and the progress of lung lesions, and showed good protection. On 26th local time, WHO held a regular press conference in COVID-19. Swaminadan said that the shortest vaccine in the world is Ebola vaccine, which takes five years. It also took two years to develop Zika virus vaccine, but it has not yet had the opportunity to conduct large-scale trials. ?
Sumiya？ Swaminathan pointed out that vaccine research and development generally takes 8 to 10 years, and WHO hopes to shorten the time as much as possible and successfully develop it within 12- 18 months, which is unprecedented and can only be achieved through global cooperation.
At present, there are more than 200 candidate vaccines in the world, of which 15 is undergoing human clinical trials. While accelerating vaccine research and development, we should expand the production equipment of various candidate vaccines in advance and produce hundreds of millions of vaccines as soon as possible. The approval of the first COVID-19 mRNA vaccine for clinical use does not mean that the vaccine has been successfully developed, but it is just around the corner.