Brucella and saponin have different inhibitory effects on Shigella flexneri, Salmonella typhi and Salmonella choleraesuis in vitro. ? Effects on cardiovascular system: Total saponins can increase coronary flow and reduce myocardial oxygen consumption in mice. It has antihypertensive effect on anesthetized dogs.
Intravenous injection of 40mg/kg (intraperitoneal injection) has a slight antipyretic effect on the fever caused by injection of typhoid and paratyphoid A mixed vaccine in rabbits, but has no obvious effect on normal body temperature and non-bacterial fever. When the dose is 20 ~ 40 mg/kg, conduction block occurs and the heart stops beating at last.
Extended data:
As a traditional national medicine, Xuedan has a history of nearly a hundred years in clinic and shows good curative effect. The research on its chemical constituents and pharmacological effects is becoming more and more mature. Cucurbitacin has good anti-tumor and anti-inflammatory effects, and the new compound of Xuebi has anti-HIV- 1 activity.
The research on the mechanism of brucine is also deepening, which provides very valuable experimental data and theoretical basis for its further development and application. The study of this genus should be further deepened in order to better develop and utilize it.
Dictyophora indusiata A and Dictyophora indusiata B can inhibit HIV- 1 reverse transcriptase, protease and release zinc ions from NCp7. In * * * culture experiment, it was found that the inhibitory effect of C8 166 cells pretreated with brucine A and brucine B on HIV- 1 was better than that of untreated cells. It is also speculated that dauricine A and dauricine B mainly play a role in the cell invasion stage of HIV- 1 virus.
Baidu Encyclopedia-Xuedan
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